酒精性肾损害的研究进展  

Research progress of alcohol-induced kidney injury

作　　者：陈星宇 刘向前[2] 高立敏 任虹 Chen Xingyu;Liu Xiangqian;Gao Limin;Ren Hong(Biobank of Union Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan 430022;Department of Histology and Embryology,School of Basic Medical Sciences,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030)

机构地区：[1]华中科技大学同济医学院附属协和医院生物样本中心,武汉430022 [2]华中科技大学同济医学院基础医学院组织学与胚胎学系,武汉430030

出　　处：《中国组织化学与细胞化学杂志》2020年第5期470-477,共8页Chinese Journal of Histochemistry and Cytochemistry

基　　金：国家自然科学基金面上项目(81771432,81371468)。

摘　　要：过量饮酒可通过直接和间接两种作用方式损害肾的结构与功能,目前认为酒精所致的氧化应激、炎症反应以及两者之间的复杂交互作用参与了酒精对肾的直接损害。对GEO数据库中2个芯片数据GSE81947和GSE83529进行分析,筛选出59个酒精对肾影响的差异基因。经检索,其中Gc、Cyp2d22、SLC22A3、Mgst1、Top2a、ArhGAP15、BDH1、Lpl、Ddx4、Agps等基因与肾的发病机制存在关联,可能是酒精性肾损害机制研究和药物筛选的潜在靶点。Excessive alcohol drinking can damage the structure and function of kidney through direct and indirect mechanisms.It is currently believed that alcohol-induced oxidative stress,inflammation and the complex interaction between these two are involved in the direct damage of alcohol to the kidney.The data in two microarrays GSE81947 and GSE83529 from GEO database were analyzed,and 59 differentially expressed genes in alcohol affected kidney were screened.Among those genes,Gc,Cyp2 d22,SLC22 A3,Mgst1,Top2 a,Arh GAP15,BDH1,Lpl,Ddx4,Agps are associated with the pathogenesis of kidney,and may be potential targets for the mechanism research and drug screening of alcohol-induced kidney injury.

关 键 词：酒精 肾损害 氧化应激 炎症反应 差异基因 

分 类 号：R692[医药卫生—泌尿科学]