基于网络药理学的丹参降糖活性成分与作用机理研究  

Studies on the Hypoglycemic Components and Mechanism of Salvia Miltiorrhizae Radix et Rhizoma by Network Pharmacology

作　　者：司秋霞 薛金涛[1] 李春燕[1,2] 张雯 王合祥 SI Qiu-xia;XUE Jin-tao;LI Chun-yan;ZHANG Wen;WANG He-xiang(School of Pharmacy,Xinxiang Medical University,Xinxiang 453002,China;Pharmaceutical Comprehensive Laboratory,Sanquan College of Xinxiang Medical University,Xinxiang 453002,China)

机构地区：[1]新乡医学院药学院,河南新乡453002 [2]新乡医学院三全学院药学综合实验室,河南新乡453003

出　　处：《海峡药学》2021年第2期13-17,共5页Strait Pharmaceutical Journal

基　　金：国家自然科学青年基金(81703458);河南省民办教育协会课题(HMXL-20190246);河南省高等学校重点科研项目(17A360026)。

摘　　要：目的揭示丹参降糖作用的主要活性成分,探讨其“成分-靶点-通路”的作用机制。方法对丹参中99个活性成分,采用反向药效团匹配方法,在Batman数据库中进行靶点收集,并与DrugBank数据库中降糖药物靶点进行比对,借助String数据库进行靶点信息关系分析,最后使用Cytoscape软件构建“成分-靶点-通路”网络关系图。结果丹参中具有降糖作用的潜在活性成分共有51个,这些降糖活性成分共涉及潜在靶点36个,信号通路213条。结论本研究采用网络药理学方法,揭示了丹参降糖作用的多成分、多靶点和多通路的作用模式,为深入研究丹参降糖活性成分与作用机理提供了理论依据。OBJECTIVE To study the active targets of the hypoglycemic bioactive components of Danshen(Salvia Miltiorrhizae Radix et Rhizoma)and investigate the“component-target-pathway”mechanism.METHODS Based on the reversed pharmacophore matching method,a total of 99 active ingredients in Danshen were used to predict the active targets and reveal the mechanism.The Batman database and DrugBank database was applied to screen the hypoglycemic targets.Additionlly,the information of these hypoglycemic targets was revealed by the String database.At last the“component-target-pathway”network was constructed with the Cytoscape software.RESULTS Danshen had 51 hypoglycemic components involved in 36 potential hypoglycemic targets and 37 signaling pathway.CONCLUSION This study applied the network pharmacology method to clarify the multi-components,multi-targets and multi-pathways of Danshen on the hypoglycemic effect,and provided a theoretical basis and a clue for further exploration of the hypoglycemic mechanism of Danshen.

关 键 词：网络药理学 丹参 糖尿病 靶点 作用机制 

分 类 号：R969.4[医药卫生—药理学]