宫颈细胞核质自动分离算法研究  

Study on Automatic Separation Algorithm of Cervical Cytoplasm

作　　者：于月娜 梁光明[2] 刘任任[1] YU Yuena;LIANG Guangming;LIU Renren(School of Information Engineering,Xiangtan University,Xiangtan 411100;School of Electronic Science and Engineering,National University of Defense Technology,Changsha 410000)

机构地区：[1]湘潭大学信息工程学院,湘潭411100 [2]国防科技大学电子科学与工程学院,长沙410000

出　　处：《计算机与数字工程》2021年第2期371-377,共7页Computer & Digital Engineering

基　　金：国家自然科学基金项目(编号:60673193)资助。

摘　　要：宫颈细胞核质分离在宫颈细胞形态学研究中是十分重要且具有挑战性的环节。论文提出了一种基于Grab Cut算法结合Canny算子边缘检测高效分离宫颈细胞核与细胞质的方法。对获取宫颈细胞图像进行灰度变化预处理求得灰度直方图,根据直方图求解确定Canny算子双阈值,进而获取宫颈细胞核和细胞质的轮廓;根据获取的轮廓利用改进的Grab Cut算法进行核质分离,并且针对Grab Cut算法进行相应改进,使其高斯混合模型的参数的确定效率提升。实验结果表明,该算法不仅有较好的分割效果而且分割准确率与效率也很高。Nuclear-cytoplasmic separation of cervical cells is a very important and challenging step in the study of cervical cell morphology.A new method for the separation of cervical nucleus and cytoplasm is proposed,which is based on the Grab Cut al⁃gorithm and Canny operator edge detection.The gray-level histogram is obtained by gray-level change pretreatment of cervical cell image,and the Canny operator double threshold is determined by histogram solution,then the contour of cervical cell nucleus and cytoplasm is obtained.According to the contour obtained,the improved Grab Cut algorithm is used to separate nucleus and cyto⁃plasm,and the corresponding improvement is made for the Grab Cut algorithm to improve the efficiency of determining parameters of the GMM.Experimental results show that the proposed algorithm not only has good segmentation effect but also has high segmenta⁃tion accuracy and efficiency.

关 键 词：宫颈细胞 核质分离 Grab Cut算法 边缘检测 双阈值 

分 类 号：TP301.6[自动化与计算机技术—计算机系统结构]