卡瑞利珠致反应性毛细血管增生症1例  

A case of reactive cutaneous capillary endothelial proliferation caused by camrelizumab

作　　者：于玲[1] 刘哲[2] 刘行梅[1] 王冬雪[1] 肖芳[1] YU Ling;LIU Zhe;LIU Xing-mei;WANG Dong-xue;XIAO Fang(Department of Pharmacy,the Second Hospital of Jilin University,Changchun 130041,China;Department of Dermatology,the Second Hospital of Jilin University,Changchun 130041,China)

机构地区：[1]吉林大学第二医院药学部,吉林长春130041 [2]吉林大学第二医院皮肤科,吉林长春130041

出　　处：《中国药物应用与监测》2021年第1期65-67,共3页Chinese Journal of Drug Application and Monitoring

摘　　要：1例55岁男性患者,因肝癌晚期伴腹腔转移,术后口服仑伐替尼(12mg,qd),1个月后抗癌方案调整为仑伐替尼联合卡瑞利珠(200mg,q2w,ivgtt),卡瑞利珠首次治疗后12d,患者双脚及脚踝出现点状鲜红色圆形丘疹,诊断为反应性皮肤毛细血管增生症(RCCEP),遂自行停用仑伐替尼,后范围进一步扩大至腰背部及口咽部黏膜,经药师劝导,患者恢复口服仑伐替尼(12mg,qd),约10d后RCCEP症状明显好转。卡瑞利珠第二次给药后约10d,患者双脚再次出现点状圆形丘疹,但较第一次程度减轻,其他部位未见皮疹。未给予特殊处置,嘱避免抓挠破溃,5d后皮疹基本消失。患者应用卡瑞利珠未再出现RCCEP,病情缓解,予以出院。A 55-year-old male patient took lenvatinib(12 mg,qd)after operation of advanced hepatocellular carcinoma with abdominal metastasis.1 month later,the therapeutic regimen changed to lenvatinib combined with camrelizumab(200 mg,q 2 w,ivgtt).On the 12th day of the first administraion of camrelizumab,he developed bright red round dot papules on both feet and ankles,which was diagnosed as reactive cutaneous capillary endothelial proliferation(RCCEP).Lenvatinib was discontinued by himself,and the papules further expanded to the lower back and oropharyngeal mucosa.The patient retook lenvatinib(12 mg,qd)advised by pharmacist and the symptoms of RCCEP improved significantly after 10 days.After about 10 days of the second administraion of camrelizumab,he developed papules on both feet again,which was less severe than the first time,and no rash was found at other parts.He was asked to avoid scratching papules and no special treatment was given to him.5 days later,the rash basically disappeared.RCCEP did not reoccurred during the course of subsequent treatment with camrelizumab.The patient was discharged from the hospital after remission.

关 键 词：仑伐替尼 卡瑞利珠 反应性毛细血管增生症 药品不良反应 

分 类 号：R969.3[医药卫生—药理学] R979.1[医药卫生—药学]