氯霉素滴眼液的稳定性研究  

Research on Stability of Chloramphenicol Eye Drops

作　　者：阮艺静 鲁方圆 谢峻 韩晓东 汪强 姜泽慧 RUAN Yi-jing;LU Fang-yuan;XIE Jun;HAN Xiao-dong;WANG Qiang;JIANG Ze-hui(Ma′anshan Food and Drug Inspection Center,Ma′anshan 243000,China;Department of Food Engineering,Ma′anshan Teacher′s College,Ma′anshan 243000,China;Inner Mongolia Key Laboratory of Plant Stress Physiology and Molecular Biology,Hohhot 010018,China)

机构地区：[1]马鞍山市食品药品检验中心,安徽马鞍山243000 [2]马鞍山市师范高等专科学校食品工程系,安徽马鞍山243000 [3]内蒙古自治区植物逆境生理与分子生物学重点实验室,内蒙古呼和浩特010018

出　　处：《海峡药学》2021年第1期1-4,共4页Strait Pharmaceutical Journal

基　　金：安徽省高校优秀青年人才支持计划项目(gxyqZD2019111);内蒙古农业大学杰出、优秀青年科学基金项目(2017XQC-2)。

摘　　要：目的研究氯霉素滴眼液稳定性的影响因素。方法设置不同的光照时间、温度和氧化剂浓度,对氯霉素滴眼液进行处理后按法定方法检测。结果光照使氯霉素含量下降,对硝基苯甲醛含量升高,pH值下降,溶液颜色改变;温度升高使氯霉素含量下降,氯霉素二醇物含量升高;过氧化氢溶液使氯霉素含量下降。结论光照、高温及氧化均会使氯霉素滴眼液含量下降,有关物质改变。OBJECTIVE To study factors affecting the stability of chloramphenicol eye drops.METHODS Status standard methods were used to evaluate chloramphenicol eye drops after being treated with different light time,temperature and oxidant concentration.RESULTS Sunlight decreased the content of chloramphenicol and pH,increased the content of nitrobenzaldehyde and changed the color of solution.The content of chloramphenicol decreased and the content of chloramphenicol glycol increased with the increase of temperature.The content of chloramphenicol decreased with hydrogen peroxide solution.CONCLUSION Sunlight,high temperature and oxidation lead to the dropping of content of chloramphenicol and change related substances.

关 键 词：氯霉素滴眼液 稳定性 高效液相色谱法 

分 类 号：R94[医药卫生—药剂学]