复方辛芷鼻腔黏附剂两种提取方法比较  

Comparison of the Two Different Extraction Methods of XinZhi Nasal Adhesion Agent

作　　者：刘梅[1] 孙全[1] 冷静[1] 侯晓军[1] 李杰 LIU Mei;SUN Quan;LENG Jing;HOU Xiao-jun;LI Jie(Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400021,China)

机构地区：[1]重庆市中医院药剂科,重庆400021

出　　处：《海峡药学》2021年第1期37-39,共3页Strait Pharmaceutical Journal

基　　金：重庆市科研院所绩效激励引导专项(名中医经验方转化应用,cstc2017jxjl130025);重庆市科技研发平台项目(中药特色制剂研发示范平台,cstc2015pt-nsjg10003);2018年度成都中医药大学杏林学者学科人才科研提升计划(YYZX20180025)。

摘　　要：目的确定复方辛芷鼻腔黏附剂的最佳提取工艺。方法采用单因素实验,以木兰脂素和欧前胡素含量为评价指标,用RP-HPLC检测指标成分的含量,考察热回流提取法和渗滤法对复方辛芷鼻腔黏附剂中目标成分的提取效率。结果用8倍量乙酸乙酯热回流提取3次(1次1 h)的方法所得目标成分的提取效率较优。结论热回流法更适用于本制剂中木兰脂素和欧前胡素的提取,提取效率高且工艺简单。OBJECTIVE To determine the best extraction process of XinZhi nasal adhesion agent.METHODS Single-factor test was adopted to investigate the effectiveness of extraction of target components in compound XinZhi nasal adhesion agent by the hot-refluxing method and the percolation extract process.In the experiment,the content of Magnolin and Imperatorin content was used as the evaluation index,and the content of index components was detected by RP-HPLC.RESULTS The optimum conditions was as a follows:the medicinal material was extracted for 3 times with 8 times amount of ethyl acetate,3 hours per time.CONCLUSION The heat-refluxing method was suitable for the extraction of the Magnolin and Imperatorin content for its simpleness and high effectiveness.

关 键 词：辛夷 白芷 木兰脂素 欧前胡素 高效液相色谱法 

分 类 号：R284[医药卫生—中药学]