2型糖尿病患者继发泌汗功能障碍影响因素及其与早期相胰岛分泌功能相关性分析  

Influencing factors of secondary sudomotor dysfunction in T2DM and its correlation with early phase pancreatic islet secretion function

作　　者：焦建虎 刘新琼 侯瑜 雷婷 向惠敏 刘洋 JIAO Jianhu;LIU Xinqiong;HOU Yu;LEI Ting;XIANG Huimin;LIU Yang(Department of Endocrinology,Tongchuan People’s Hospital,Tongchuan 727100,China)

机构地区：[1]铜川市人民医院内分泌科,陕西铜川727100 [2]铜川矿务局中心医院内分泌科,陕西铜川727000

出　　处：《陕西医学杂志》2021年第3期330-333,共4页Shaanxi Medical Journal

摘　　要：目的:探讨2型糖尿病(T2DM)患者继发泌汗功能障碍影响因素及其与早期相胰岛分泌功能相关性。方法:回顾性分析770例T2DM患者临床资料,根据是否继发泌汗功能障碍分为泌汗功能正常组(524例)和泌汗功能障碍组(246例)。比较两组患者一般临床资料和实验室指标[尿酸(UA)、糖化血红蛋白(HbA1c)、泌汗功能障碍组糖负荷30 min净增C肽与葡萄糖(ΔC-P30/ΔG30)、净增胰岛素与葡萄糖比值(ΔI30/ΔG30)、120 min血糖曲线下面积(AUC)校正后的C肽和胰岛素AUC(I-AUC/G-AUC与C-P-AUC/G-AUC)等]。T2DM继发泌汗功能障碍与早期相胰岛分泌功能相关性采用Spearman相关性分析。T2DM继发泌汗功能障碍的独立影响因素采用多元逐步线性回归法分析。结果:泌汗功能障碍组年龄和病程均高于泌汗功能正常组(均P<0.05)。泌汗功能障碍组ΔC-P30/ΔG30、ΔI30/ΔG30、I-AUC/G-AUC及C-P-AUC/G-AUC均低于泌汗功能正常组(均P<0.05)。Spearman相关性分析结果显示,ΔC-P30/ΔG30、ΔI30/ΔG30与HESC和FESC均呈正相关(均P<0.05)。多元逐步线性回归分析结果显示,ΔC-P30/ΔG30、病程、年龄、HbA1c及UA是T2DM继发泌汗功能障碍独立影响因素(均P<0.05)。结论:T2DM继发泌汗功能障碍与ΔC-P30/ΔG30、病程、年龄、HbA1c及UA独立相关,其中早期相胰岛分泌功能损伤越严重者继发泌汗功能障碍风险越高。Objective:To investigate the influencing factors of secondary sudomotor dysfunction in T2DM and its correlation with early phase pancreatic islet secretion function.Methods:Clinical data of 770 patients with T2DM were retrospectively analyzed.According to whether secondary sudomotor dysfunction occurred,they were divided into normal sudomotor group(524 cases)and sudomotor dysfunction group(246 cases).The general clinical data and laboratory indexes were compared between the two groups.Spearman correlation analysis was used to analyze the correlation between secondary sudomotor dysfunction and early phase pancreatic islet secretion function.Multiple stepwise linear regression analysis was used to analyze the independent influencing factors of secondary sudomotor dysfunction in T2DM.Results:The age and course of disease in sudomotor dysfunction group were higher than those in normal sudomotor group(all P<0.05).The levels ofΔC-P30/ΔG30,ΔI30/ΔG30,I-AUC/G-AUC,C-P-AUC/G-AUC in sudomotor dysfunction group were lower than those in normal sudomotor group(all P<0.05).Spearman correlation analysis showed thatΔC-P30/ΔG30 andΔI30/ΔG30 were positively correlated with HESC and FESC(all P<0.05).Multiple stepwise linear regression analysis showed thatΔC-P30/ΔG30,course of disease,age,HbA1c and UA were independent influencing factors of secondary sudomotor dysfunction in T2DM(all P<0.05).Conclusion:The secondary sudomotor dysfunction in T2DM is independently related toΔC-P30/ΔG30,course of disease,age,HbA1c and UA.The more severe the early phase of pancreatic islet secretion dysfunction,the higher the risk of secondary sudomotor dysfunction.

关 键 词：2型糖尿病 糖尿病周围神经病变 泌汗功能 影响因素 胰岛功能 相关性分析 

分 类 号：R587.1[医药卫生—内分泌]