肾炎舒片联合还原型谷胱甘肽对慢性肾小球肾炎患者血清IL-1、TNF-α、IL-6和尿液mALB的影响  

Effect of Shenyanshu tablets combined with reduced glutathione on serum IL-1,TNF-α,IL-6 and urine mALB in patients with chronic glomerulonephritis

作　　者：张瑶琳[1] 葛琪容 罗海波 乔建芬 林建美 戴传强 Zhang Yaolin;Ge Qirong;Luo Haibo;Qiao Jianfen;Lin Jianmei;Dai Chuanqiang(Department of Nephrology, Ziyang First People's Hospital, Sichuan Province,Ziyang 641300,China)

机构地区：[1]四川省资阳市第一人民医院肾病内科,641300

出　　处：《疑难病杂志》2021年第3期246-250,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：四川省医学会课题(2019SAT17)。

摘　　要：目的探讨肾炎舒片联合还原型谷胱甘肽对慢性肾小球肾炎患者血清IL-1、TNF-α、IL-6和尿液mALB水平的影响。方法选取2017年8月—2019年8月四川省资阳市第一人民医院肾内科住院治疗的慢性肾小球肾炎患者64例作为研究对象,按照随机数字表法分为对照组和观察组各32例,对照组患者给予还原型谷胱肽片口服,观察组在对照组的基础上给予肾炎舒片口服,2组疗程均为4周。比较2组治疗前后肾功能[血清尿素氮(BUN)、肌酐(SCr)、内生肌酐清除率(CCr)],炎性因子[血清白介素-1(IL-1)、IL-6、肿瘤坏死因子α(TNF-α)、干扰素γ(IFN-γ)],血清免疫球蛋白(IgA、IgG、IgM),尿蛋白指标[尿微量蛋白(mALB)、血清胱抑素C(Cysc)、尿β2微球蛋白(β2-MG)]等指标变化。结果治疗后,观察组总有效率为96.88%,高于对照组的68.75%(χ^(2)/P=4.777/0.029)。治疗4周后,2组患者的血清BUN、SCr、CysC、NGAL指标均低于治疗前(P<0.05),尿NGAL、24h-Upro、尿mALB、β2-MG指标均低于治疗前,差异均有统计学意义(P<0.05),CCr低于治疗前(P<0.05);血清炎性因子IL-1、IL-6、TNF-α、IFN-γ水平均低于治疗前,具有显著性差异(P<0.05);血清IgA、IgG、IgM水平均高于治疗前,差异有统计学意义(P<0.05)。且上述各项指标比较,观察组均优于对照组(P<0.05)。结论肾炎舒片与还原型谷胱甘肽联合治疗,慢性肾小球肾炎患者肾功能恢复明显,有效降低血清中IL-1、IL-6、TNF-α、IFN-γ水平及尿mALB等实验室指标,临床疗效显著。Objective To explore the effect of Shenyanshu tablets combined with reduced glutathione on serum IL 1,TNFα,IL 6 and urine mALB levels in patients with chronic glomerulonephritis.Methods From August 2017 to August 2019,64 patients with chronic glomerulonephritis who were hospitalized in the Department of Nephrology,First People's Hospital of Ziyang City,Sichuan Province were selected as the research objects.According to the random number table,they were divided into control group and observation group with 32 cases each Patients in the control group were given oral reduced glutathione tablets,and the observation group was given oral administration of Shenyanshu tablets based on the control group.The course of treatment in both groups was 4 weeks.Compare the serum urea nitrogen(BUN),serum creatinine(SCr),endogenous creatinine clearance(CCr);interleukin 1(IL-1),IL-6,tumor necrosis factorα(TNF-α),interferonγ(IFN-γ);serum immunoglobulin(IgA,IgG,IgM);urine microalbumin(mALB),serum cystatin C(Cysc),urineβ2 microglobulin(β2-MG)and other indicators.Results After treatment,the total effective rate of the observation group was 96.88%higher than that of the control group 68.75%(χ^(2)/P=4.777/0.029).After treatment,the BUN,SCr,blood CysC,and blood NGAL indexes of the two groups of patients were all lower than before treatment(P<0.05),and the indexes of urine NGAL,24h Upro,urine mALB,andβ2-MG were all lower than those of the patients before treatment,and they were all significant Difference(P<0.05),CCr was lower than before treatment(P<0.05).The levels of serum inflammatory factors IL-1,IL-6,TNF-α,and IFN-γwere lower than before treatment,with significant difference(P<0.05).Serum IgA,IgG and IgM levels were higher than before treatment,the difference was statistically significant(P<0.05).In addition,the observation group is better than the control group(P<0.05).Conclusion The combined treatment of Shenyanshu tablets and reduced glutathione can significantly restore renal function in patients with chronic glomerulone

关 键 词：慢性肾小球肾炎 肾炎舒片 还原型谷胱甘肽 血清炎性因子 尿微量蛋白 

分 类 号：R692.3[医药卫生—泌尿科学]