气道上皮细胞损伤修复在哮喘中的研究进展  

Research progress of airway epithelial cell damage and repair in asthma

作　　者：金明珠[1] 陈晓秋(综述)[1] 李钰[2] 曹志伟(审校)[1] Jin Mingzhu;Chen Xiaoqiu;Li Yu;Cao Zhiwei(Department of Rhinology,Shengjing Hospital of China Medical University,Shenyang 110004,China;不详)

机构地区：[1]中国医科大学附属盛京医院鼻科,110004 [2]中国医科大学附属盛京医院第一呼吸内科,110004

出　　处：《疑难病杂志》2021年第3期315-319,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：吴阶平医学基金会临床科研专项资助基金(320.6750.18236);辽宁省教育厅科学研究经费项目(JC2019010)。

摘　　要：气道上皮细胞是肺内环境与外界环境之间的第一道屏障,损伤修复功能是其维持屏障作用、保护内环境稳态的重要因素。目前研究认为,哮喘患者气道上皮细胞损伤修复功能下降,并导致气道炎性反应加重。气道炎性反应过程中分泌的炎性因子也会显著影响上皮细胞损伤修复功能。由于人体内损伤修复研究的局限性,人们探索出多种损伤修复模型,并利于各自的不同特点,寻找改善哮喘患者气道上皮细胞损伤修复功能的方法,为哮喘的治疗寻找新的靶点。Airway epithelial cells are the first barrier between the lung environment and the external environment.The damage repair function is an important factor in maintaining the barrier function and protecting the homeostasis of the internal environment.Current studies suggest that the damage and repair function of airway epithelial cells in asthmatic patients is reduced,and the airway inflammatory response is aggravated.Inflammatory factors secreted in the process of airway inflammation can also significantly affect the function of epithelial cell damage and repair.Due to the limitations of human injury repair research,people have explored a variety of injury repair models,which are conducive to their different characteristics,looking for ways to improve the injury and repair function of airway epithelial cells in patients with asthma,and find new targets for the treatment of asthma.

关 键 词：哮喘 气道上皮细胞 损伤修复 

分 类 号：R562.25[医药卫生—呼吸系统]