内源性大麻素抗肺纤维化的作用研究进展  

Research progress on the anti-pulmonary fibrosis effect of endocannabinoids

作　　者：喻娟娟(综述) 欧维琳(审校)[1] Yu Juanjuan;Ou Weilin(Department of Pediatrics, the Affiliated Hospital of Guilin Medical University, Guangxi Provine,Guilin 541000,China)

机构地区：[1]桂林医学院附属医院儿科,541000

出　　处：《疑难病杂志》2021年第3期320-324,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金资助项目(81360248);广西自然科学基金资助项目(2014GXNSFAA18171)。

摘　　要：肺纤维化作为临床常见的呼吸系统危重症,病因及发病机制复杂,最终导致呼吸衰竭,严重影响患者的生活质量。在肺组织、支气管平滑肌细胞、内皮细胞存在内源性大麻素和相应的大麻素受体,内源性大麻素与大麻素受体结合后可能通过磷脂酰肌醇-3激酶/蛋白激酶(PI3K/Akt)信号通路和TGF-β_(1)/Smad3信号通路参与调节免疫反应,抑制炎性细胞分泌细胞因子,减轻炎性反应,并且抑制血管内皮生长因子、基质金属蛋白酶等表达,抑制基底膜增生,发挥抗纤维化作用。文章就内源性大麻素在抗肺纤维化中的作用进行综述。Pulmonary fibrosis,as a common clinical critical illness of the respiratory system,has complex etiology and pathogenesis,which eventually leads to respiratory failure and seriously affects the quality of life of patients.There are endocannabinoids and corresponding cannabinoid receptors in lung tissue,bronchial smooth muscle cells,and endothelial cells.The binding of endocannabinoids to cannabinoid receptors may pass through phosphatidylinositol 3 kinase/protein kinase(PI3K/Akt)signaling pathway and TGF-β_(1)/Smad3 signaling pathway are involved in regulating immune response,inhibiting inflammatory cells from secreting cytokines,reducing inflammatory response,and inhibiting the expression of vascular endothelial growth factor,matrix metalloproteinases,etc.,inhibiting basement membrane proliferation,and exerting anti-fiber Effect.This article reviews the role of endocannabinoids in anti-pulmonary fibrosis.

关 键 词：肺纤维化 内源性大麻素 大麻素受体 调节通路 

分 类 号：R563.9[医药卫生—呼吸系统]