MEX3C在不同卵巢储备功能患者颗粒细胞中的表达  

Expression of MEX3C in granular cells of patients with different ovarian reserve function

作　　者：陈琰[1] 宋梦玲[1] 马小红[1] 李永丽[1] 马丽丽[1] 刘春莲[1] 杨海燕[1] 李彩艳[1] 徐仙[1] CHEN Yan;SONG Mengling;MA Xiaohong;LI Yongli;MA Lili;LIU Chunlian;YANG Haiyan;LI Caiyan;XU Xian(The Center for Reproductive Medicine,General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学总医院生殖医学中心,宁夏银川750004

出　　处：《宁夏医学杂志》2021年第2期99-101,共3页Ningxia Medical Journal

基　　金：国家自然科学基金地区科学基金项目(81560261);宁夏自然科学基金项目(NZ17176);宁夏医科大学校级项目(XY2017197)。

摘　　要：目的探讨不同卵巢储备功能人群中MEX3RNA结合蛋白家族C (MEX3C)在颗粒细胞中的表达差异,并分析与卵巢功能的相关性。方法选取因输卵管因素行体外受精-胚胎移植(IVF-ET)治疗的不孕妇女55例,分为卵巢储备正常组(A组)20例,卵巢储备升高组(B组)20例,卵巢储备降低组(C组)15例。收集各组患者颗粒细胞,采用Western blot检测各组颗粒细胞中MEX3C表达水平。结果卵巢储备降低组MEX3C表达水平显著低于卵巢储备正常组(P<0.05);卵巢储备升高组MEX3C表达水平显著高于卵巢储备正常组(P<0.05)。结论不同卵巢储备功能患者卵巢颗粒细胞MEX3C表达水平存在差异,可为评估卵巢储备功能、促进卵泡发育提供理论依据。Objective To investigate the different expression of MEX3C in granulosa cells with different ovarian reserves function and analyzed the correlation between MEX3C and ovarian function.Methods A total of 55 infertile women who underwent IVF-ET treatment due to fallopian tubal factors were divided into normal ovarian reserve group(group A,n=20),increased ovarian reserve group(group B,n=20)and decreased ovarian reserve group(group C,n=15).The granulosa cells of patients in each group were collected.The expression levels of MEX3C in granulosa cells were detected by Western blot.Results The expression levels of MEX3C in the decreased ovarian reserve group were significantly lower in the normal ovarian reserve function group(P<0.05),The expression levels of MEX3C in the increased ovarian reserve group were significantly higher than normal ovarian reserve group(P<0.05).Conclusion The expression levels of MEX3C in ovarian granulosa cells of patients with different ovarian reserve functions are different,which can provide theoretical basis for evaluating ovarian reserve function and promoting follicular development.

关 键 词：体外受精-胚胎移植 卵巢储备功能 卵巢颗粒细胞 MEX3 RNA结合蛋白家族C 

分 类 号：R715.5[医药卫生—妇产科学]