银屑病患者外周血淋巴细胞亚群的变化  

Changes of peripheral blood lymphocyte subsets in patients with psoriasis

作　　者：刘燕敏 赵新程[1] 李俊琴[1] 张开明[1] LIU Yan-min;ZHAO Xin-cheng;LI Jun-qin;ZHANG Kai-ming(Shanxi Key Laboratory of Stem Cell for Immunological Dermatosis, Dermatology Laboratry, Department of Dermatology,Taiyuan Central Hospital of Shanxi Medical University, Taiyuan 030009, China)

机构地区：[1]山西医科大学附属太原中心医院皮肤科,皮肤病学实验室,免疫性皮肤病干细胞山西省重点实验室,山西太原030009

出　　处：《基础医学与临床》2021年第3期415-418,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(8177333)。

摘　　要：目的探讨进行期、静止期和退行期的银屑病患者外周血淋巴细胞亚群的变化及免疫机制。方法本研究评估了77例寻常型银屑病患者(28例进行期、23例静止期、26例退行期)的外周血单个核细胞(PBMCs)各组中各淋巴细胞的比率。结果与退行期相比,进行期和静止期患者的CD3^(+)、CD4^(+)和CD8^(+)淋巴细胞的百分率均显著升高(P<0.01)。同进行期比较,静止期和退行期的CD4-CD8-淋巴细胞的百分率降低(P<0.05)。CD3^(-)CD16^(+)CD56^(+)比例随病情稳定而增高,CD45^(+)CD14^(+)比例逐渐下降和CD3^(-)CD19^(+)与病情呈负相关,3组的差异显著(P<0.05)。结论进行期、静止期和退行期3组银屑病患者的淋巴细胞亚群存在显著的差异,进一步支持银屑病的免疫发病机制。Objective To investigate the changes and immune mechanisms of peripheral blood lymphocyte subsets in psoriasis patients with progressive,stationary and regression stages.Methods The percentage of lymphocytes in each group of peripheral blood mononuclear cells(PBMCs)in 77 patients with psoriasis vulgaris including 28 patients during progression,23 patients during stationary,and 26 patients during regression.ResultsThe percentages of CD3^(+),CD4^(+)and CD8^(+)lymphocytes were significantly increased in both the progression and stationary stages as compared to the regression stage(P<0.01).CD4-and CD8-subsets in the peripheral blood lymphocyte subsets of the patients showed a decreasing trend according to progression,stationary and regression stages(P<0.05).The result showed that the proportion of CD3^(-)CD16^(+)CD56^(+)increased with the stability of the disease,the proportion of CD45^(+)CD14^(+)gradually decreased,and the proportion of CD3^(-)CD19^(+)was negatively correlated with the disease(P<0.05).Conclusions There are significant differences in lymphocyte subsets in the three groups of patients with psoriasis,which further supported the immune pathogenesis of psoriasis.

关 键 词：银屑病 T淋巴细胞 白细胞 B淋巴细胞 

分 类 号：R75[医药卫生—皮肤病学与性病学]