糠酸莫米松乳膏联合含青刺果及金盏花提取物护肤品治疗婴幼儿湿疹的疗效观察  

Application of mometasone furoate cream plus prinsepia utilis royle and calendula extracts on treatment of eczema

作　　者：叶诏炜 YE Zhao-wei(Department of Child Health,Maternal and Child Health Hospital,Yuexiu District,Guangzhou City,Guangzhou,Guangdong 510030,China)

机构地区：[1]广州市越秀区妇幼保健院儿童保健科,广东广州510030

出　　处：《皮肤病与性病》2020年第6期793-795,共3页Dermatology and Venereology

摘　　要：目的观察糠酸莫米松乳膏联合含青刺果及金盏花提取物护肤品(薇诺娜宝贝舒润滋养霜)治疗婴幼儿湿疹的临床效果。方法纳入2018年4月至2019年4月期间某妇幼保健院收治的140例湿疹患儿作为研究对象,按随机数字表法分为对照组、治疗组各70例。治疗组70例患儿采用糠酸莫米松乳膏(艾洛松)联合宝贝舒润滋养霜治疗,早、晚间采用宝贝舒润滋养霜全身涂抹,10min后再给艾洛松乳膏薄层涂于患处并轻揉至吸收;对照组70例患儿采用艾洛松治疗,早、晚间外用艾洛松乳膏各1次。治疗2周。2周后治疗组和试验组进行疗效评估,然后两组均停用艾洛松,治疗组继续每日早晚各用1次宝贝舒润滋养霜。停药3个月后观察两组患儿皮损SCORDA评分、总改善率、经皮水分丢失、角质层含水量以及不良反应情况。结果治疗组患儿皮损SCORAD评分明显低于对照组,差异有统计学意义(P<0.05)。治疗组患儿总改善率为92.86%;对照组患儿总改善率为78.57%。治疗组患儿总改善率明显高于对照组,差异有统计学意义(P<0.05)。治疗组经皮水分丢失量明显少于对照组,皮损角质层含水量明显高于对照组,差异有统计学意义(P<0.05)。治疗组不良反应发生率为7.14%,对照组不良反应发生率为11.43%,两组对比差异无统计学意义(P>0.05)。结论宝贝舒润滋养霜能明显改善湿疹患儿的皮损情况,促进治疗效果,保持皮肤水分,安全性较高,值得临床应用及推广。Objective To study the application of mometasone furoate cream plus prinsepia utilis royle and calendula extracts(Winona baby nourishing skin cream)on treatment of eczema.Methods 140 eczema infants treated from April 2018 to April 2019 in our hospital were selected as research subjects.According to random number table,infants were divided into two groups,70 cases in each group.For treatment group,bay nourishing skin cream was smeared from head to foot in the morning and evening while eloson cream was smeared and rubbed after 10min of smearing.For control group,eloson was smeared for once in the morning and evening.After two weeks of treatment courses,curative effects were appraised and eloson was suspended.Meanwhile,the treatment group still took bay nourishing skin cream in the morning and evening.After 3m of the recurrence rate,SCORDA scores,overall improvement rate,transepidermal water loss,cuticle water content and adverse reactions were explored.Results SCORAD scores in the treatment group were lower than control group,with statistically significant difference(P<0.05);overall improvement rate in the treatment group(92.86%)was higher than control group(78.57%);(P<0.05);transepidermal water loss in the treatment group was smaller than control group;cuticle water content was larger than control group(P<0.05);adverse event rate in the treatment group(7.14%)and control group(11.43%)showed no statistically significant difference(P>0.05).Conclusion The baby nourishing skin cream can reduce the skin damage and recurrence rate,keep the skin moisture,and increase the treatment effects and safety.It is worthy of clinical application and promotion.

关 键 词：宝贝滋养霜 湿疹 特应性皮炎 

分 类 号：R751.05[医药卫生—皮肤病学与性病学] R758.23[医药卫生—临床医学]