兽用抗菌药耐药性风险评估研究进展  

Research progress of risk assessment on veterinary antimicrobial resistance

作　　者：安博宇 胡蔓 徐向月 马文瑾 黄玲利[3] 王福南 戴梦红[1] 袁园园 程古月[1] An Bo-yu;Hu Man;Xu Xiang-yue;Ma Wen-jin;Huang Ling-li;Wang Fu-nan;Dai Meng-hong;Yuan Yuan-yuan;Cheng Gu-yue(MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products,Huazhong Agricultural University,Wuhan 430070;Wuhan Wuchang Hospital(Wuchang Hospital Affiliated to Wuhan University of Science and Technology),Wuhan 430070;National Reference Laboratory of Veterinary Drug Residues(HZAU)and MAO Key Laboratory for Detection of Veterinary Drug Residues,Huazhong Agricultural University,Wuhan 430070)

机构地区：[1]华中农业大学农业部畜禽产品质量安全风险评估实验室,武汉430070 [2]武汉市武昌医院(武汉科技大学附属武昌医院),武汉430063 [3]华中农业大学国家兽药残留基准实验室(HZAU),农业部食品兽药残留检测重点实验室,武汉430070

出　　处：《中国抗生素杂志》2021年第1期27-33,共7页Chinese Journal of Antibiotics

基　　金：十三五国家重点研发计划(No.2018YFD0500300、No.2017YFC1600100);国家自然科学基金(No.31502115);湖北省自然科学基金(No.2017CFB445)。

摘　　要：随着我国畜牧业的快速发展,兽用抗菌药物被大量使用于动物身上,并且用量逐年上升。由于兽用抗菌药物的不合理使用,引发了耐药性的产生,从而出现了一系列治疗失败问题,给人类健康造成了潜在的危害。因此抗菌药物的使用对人和动物健康所造成的风险受到广泛关注,目前兽用抗菌药物风险评估技术已被广泛用于预测药物引发的耐药性风险大小,揭示兽用抗菌药物的使用产生的对人和动物健康造成威胁的耐药性风险。本文主要对国内外开展的兽用抗菌药耐药性风险评估的研究进行综述,为我国开展耐药风险评估提供借鉴。With the rapid development of animal husbandry in China, a large number of antibacterial drugs for veterinary use have been used on animals, and the amount has increased year by year. Due to the irrational use of antibacterial drugs for veterinary use, drug resistance was triggered, and a series of treatment failures appeared, which caused potential harm to animals and human health. Therefore, the risks caused by the use of antibacterial drugs to human and animal health have received widespread attention. At present, veterinary antibacterial drug risk assessment techniques have been widely used to predict the risk of drug-induced resistance, and to reveal the risks caused by the use of antibacterial drugs and the risk of drug resistance that poses a threat to human and animal health. This article mainly reviews the research on the risk assessment of antimicrobial resistance in veterinary medicine at home and abroad, and provides a reference for the development of drug resistance risk assessment in China.

关 键 词：兽用抗菌药 耐药性 风险分析 风险评估 

分 类 号：R978.1[医药卫生—药品]