高分辨MRI测量中国健康成人海马及其亚区体积  

High-resolution MRI measuring volume of hippocampus and its subregions in healthy Chinese adults

作　　者：张泽寅 梁佩鹏 王颖[1] 杜佳晨 李倩倩 李坤成[1,4] ZHANG Zeyin;LIANG Peipeng;WANG Ying;DU Jiachen;LI Qianqian;LI Kuncheng(Department of Radiology and Nuclear Medicine,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Department of Radiology,the Central Hospital of Beijing Prison,Beijing 100054,China;School o Psychology,Capital Normal University,Beijing 100048,China;Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院放射与核医学科,北京100053 [2]北京市监狱管理局中心医院放射科,北京100054 [3]首都师范大学心理学院,北京100048 [4]磁共振成像脑信息学北京市重点实验室,北京100053

出　　处：《中国医学影像技术》2021年第2期169-173,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家重点研发计划课题(2020YFC2007302);北京市科技计划课题(Z171100000117001);北京市优秀人才青年拔尖团队项目(2016000021223TD07);磁共振成像脑信息学北京重点实验室专项基金资助。

摘　　要：目的测量中国健康成人海马及其亚区体积,获得海马体积正常参考值,观察年龄、性别与海马及其亚区体积的关系。方法自中国健康成人头颅MRI数据库(Chinese 1000)中抽取100名数据,手动测量海马及其亚区体积,对标准化后的测量结果进行统计学分析。结果各年龄段男、女性双侧海马及其亚区体积差异均无统计学意义(P均>0.05)。18~30岁男性左侧海马头体积大于女性(P=0.006)。女性双侧海马体、右侧海马尾体积均大于男性(P均<0.05)。男、女性右侧海马总体积和海马头体积均大于左侧(P均<0.001)。结论海马总体积呈右偏侧化,无显著性别差异;18~30岁健康男性左侧海马头体积大于女性,女性双侧海马体、右侧海马尾体积大于男性。Objective To obtain the normal reference values of volume of hippocampus and its subregions,and to explore the relationships of age,gender and the volume of hippocampus and its subregions in Chinese healthy adults.Methods Data of 100 subjects were selected from Chinese healthy adult head MRI database(Chinese 1000).The volume of hippocampus and its subregions were manually measured,and the results were statistically analyzed after standardized processing.Results There was no significant difference of volume of bilateral hippocampus and subregions between males and females of all ages(all P<0.05).The volume of left hippocampal head in males of 18-30 years old was larger than that in females(P=0.006),of bilateral hippocampal body and right hippocampal tail in females were larger than in males(all P<0.05).The total hippocampal volume and hippocampal head volume on the right side were all greater than those on the left side in both males and females(all P<0.001).Conclusion The volume of hippocampus was right lateralized,without significant difference between males and females.Among 18-30 years old healthy adults,the volume of left hippocampal head in males was larger than that in females,while the volume of bilateral hippocampal body and right hippocampal tail in females were all larger than those in males.

关 键 词：海马 成人 脑 体积 磁共振成像 

分 类 号：R332.81[医药卫生—人体生理学] R445.2[医药卫生—基础医学]