神经递质和调质参与导水管周围灰质痛觉调控的研究进展  

Neurotransmitters and Modulators of Periaqueductal Gray That Involved in Pain Regulation

作　　者：严传婷 杜宜楠 韩静[1] 任维[1] 刘志强[1] YAN Chuan-Ting;DU Yi-Nan;HAN Jing;REN Wei;LIU Zhi-Qiang(Key Laboratory of Modern Teaching Tochnology Ministry of Education,Shaanxi Normal University,Xi'an710062,China)

机构地区：[1]陕西师范大学现代教学技术教育部重点实验室,西安710062

出　　处：《生物化学与生物物理进展》2021年第2期158-170,共13页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(11727813,91949105);陕西师范大学学习科学交叉学科建设资助项目。

摘　　要：导水管周围灰质(periaqueductal gray,PAG)在疼痛的调控过程中处于一个不可或缺的位置.其不仅是痛觉信息上行传递的重要部位,还是疼痛抑制系统的重要组成部分.在PAG,包括γ-氨基丁酸(γ-aminobutyric acid,GABA)、5-羟色胺(5-hydroxytryptamine,5-HT)和谷氨酸(glutamate,Glu)在内的神经递质以及内源性阿片肽(endogenous opioid peptides,EOP)和内源性大麻素(endocannabinoid,e CB)为代表的神经调质都参与了PAG对疼痛的信息传递以及调节.本文重点综述GABA、5-HT、Glu、EOP和eCB在PAG参与疼痛生理调控机制的研究进展,以期为中枢神经系统的镇痛研究提供一定的理论基础.Periaqueductal gray(PAG)plays an important role in pain modulation.It is not only an important participant of ascending pain transmission pathways,but also a critical part of descending pain modulation pathways.In PAG,there are evidences that several neurotransmitters(such asγ-aminobutyric acid,5-hydroxytryptamine,glutamate)and neuromodulators(such as endogenous opioid peptide,cannabinoid)are involved in the information transmission and functional regulation of pain.PAG not only regulates pain locally through their own level changes and interaction of these factors,but also regulates pain by receiving fiber projections from other brain regions and sending fiber projections to other pain related brain regions.For example,the analgesic effect of the increased level of GABA in PAG could be realized by the effect of opioid peptides on GABAergic interneurons,or driven directly by the fiber projection from cortex to the GABAergic interneurons in PAG.GABAergic neurons in PAG can also regulate pain by affecting the NAergic fibers projected from A7 cells to the spinal cord.Thus,PAG participates pain modulation in complicated and multiple ways.

关 键 词：导水管周围灰质 痛觉调控 神经递质 神经调质 受体 

分 类 号：R338.3[医药卫生—人体生理学]