逍遥散合化痰通络汤加盐酸度洛西汀片治疗抑郁症的临床效果  

Clinical effect of Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Tablets in the treatment of depression

作　　者：李世强 王玮 宋颖 卫景沛 LI Shiqiang;WANG Wei;SONG Ying;WEI Jingpei(The First Department of Neurology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院脑病一科,北京100700

出　　处：《中国医药导报》2021年第4期111-114,共4页China Medical Herald

基　　金：“十二五”国家科技支撑计划课题(2013BAIl3B02);中央高校基本科研业务费专项资金资助项目(2018-JYBZZ-JS071)。

摘　　要：目的探讨逍遥散合化痰通络汤加盐酸度洛西汀片治疗抑郁症的临床效果。方法采取随机、对照、盲法的原则,选取2018年1月—2019年8月于北京中医药大学东直门医院门诊及住院的肝郁脾虚型抑郁症患者90例,根据随机数字表法将其分为西药组、中药组、联合组,各30例。西药组口服盐酸度洛西汀肠溶片,中药组口服逍遥散合化痰通络汤颗粒,联合组同时服用逍遥散合化痰通络汤颗粒剂和盐酸度洛西汀肠溶片,均治疗6周。观察三组抑郁症疗效、中医证候疗效及治疗前后汉密尔顿抑郁量表(HAMD)评分、中医证候量表评分。结果联合组抑郁症总有效率、中医证候总有效率均高于西药组及中药组,差异有统计学意义(P<0.017)。整体分析发现,HAMD评分和中医证候量表评分的组间效应、时间效应差异均有统计学意义(P<0.05),交互作用差异无统计学意义(P>0.05)。组内比较:三组治疗3、6周后HAMD评分和中医证候量表评分均较治疗前降低(P<0.05)。组间比较:联合组治疗3、6周后HAMD评分及中医证候量表评分均低于西药组和中药组,差异有统计学意义(P<0.05)。结论逍遥散合化痰通络汤加盐酸度洛西汀肠溶片治疗抑郁症的效果好,可在临床上作为较为理想的方法治疗抑郁症。Objective To investigate clinical effect of Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Tablets in the treatment of depression.Methods By using the principle of random,controlled and blind method,a total of 90 outpatients and inpatients with depression of liver depression and spleen deficiency type in Dongzhimen Hospital of Beijing University of Chinese Medicine from January 2018 to August 2019 were selected and divided into Western medicine group,Chinese medicine group and combination group according to the random number table method,with 30 cases in each group.Western medicine group was treated with Duloxetine Hydrochloride Enteric-coated Tablets,Chinese medicine group was treated with Xiaoyao Powder combined with Huatan Tongluo Decoction,combination group was treated with Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Enteric-coated Tablets.All patients were treated for six weeks.The curative effect of depression,curative effect of Chinese medicine symptoms,Hamilton depression scale(HAMD)score and Chinese medicine syndrome scale score before and after treatment among three groups were observed.Results Total effective rate of depression,total effective rate of Chinese medicine syndrome in combination group were higher than those in Western medicine group and Chinese medicine group(P<0.017).Overall analysis found that there were significant differences in HAMD score and Chinese medicine syndrome scale score between inter group effect and time effect(P<0.05),but there was no significant difference in interaction(P>0.05).Intra group comparison:HAMD score and Chinese medicine syndrome scale score of three groups at three and six weeks after treatment were lower than those before treatment(P<0.05).Comparison between groups:HAMD score and Chinese medicine syndrome scale score of combination group were lower than those of Western medicine group and Chinese medicine group at three and six weeks of treatment,the differences were statistically sig

关 键 词：逍遥散 化痰通络汤 盐酸度洛西汀 抑郁症 

分 类 号：R277.7[医药卫生—中医学]