辛伐他汀胶囊和阿托伐他汀钙片治疗动脉粥样硬化患者的药物经济学评价  

Pharmacoeconomic Evaluation of Simvastatin Capsules and Atorvastatin Calcium Tablets in the Treatment of Patients with Atherosclerosis

作　　者：张宁[1] 马艳 王蓉 ZHANG Ning;MA Yan;WANG Rong(Department of Pharmacy,Dalian Hospital of Traditional Chinese Medicine,Dalian 116013,China;Department of Pharmacy,Dalian Central Hospital,Dalian 116300,China)

机构地区：[1]大连市中医医院药剂科,辽宁大连116013 [2]大连市中心医院药剂科,辽宁大连116300

出　　处：《中国药物经济学》2021年第1期31-34,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨辛伐他汀胶囊和阿托伐他汀钙片治疗动脉粥样硬化患者的疗效,并进行药物经济学评价。方法选取2017年9月至2019年2月大连市中医医院收治的94例动脉粥样硬化患者作为研究对象,按用药方法不同分为两组,对照组(n=45)给予阿托伐他汀钙片治疗,观察组(n=49)给予辛伐他汀胶囊治疗。比较两组患者的治疗效果、超敏C反应蛋白(hs-CPR)、颈动脉内膜中层厚度(IMT)、胱抑素C(CysC)水平、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、三酰甘油(TG)、金属基质蛋白酶-9(MMP-9)、白细胞介素-6(IL-6)水平、不良反应发生率,并进行药物经济学评价。结果观察组治疗有效率89.80%高于对照组有效率的88.89%,组间比较,差异无统计学意义(P>0.05);治疗后,观察组hs-CPR、CIMT、CysC显著低于对照组,差异有统计学意义(P<0.05);治疗后,观察组TG、TC、LDL-C水平低于对照组,但差异无统计学意义(P>0.05);治疗后,观察组IL-6、MMP-9水平低于对照组,但差异无统计学意义(P>0.05);观察组不良反应发生率为6.12%,与对照组不良反应发生率为6.67%比较,差异无统计学意义(P>0.05);观察组治疗成本为28.56元,对照组为483.84元,观察组治疗方案更具有药物经济学优势。结论辛伐他汀胶囊治疗动脉粥样硬化临床效果较好,能够有效缓解临床症状,且在药物经济学方面存在优势。Objective To explore the efficacy of simvastatin capsules and atorvastatin calcium tablets in the treatment of atherosclerosis,and to conduct pharmacoeconomic evaluation.Methods According to different medication methods,a total of 94 patients with atherosclerosis received in Dalian Hospital of Traditional Chinese Medicine from September 2017 to February 2019 were divided into 2 groups:a control group and a research group.The control group(n=45)was given atorvastatin calcium tablets treatment,while the observation group(n=49)was given simvastatin capsules.The curative effect,high-sensitivity C-reactive protein(hs-CPR),carotid intima-media thickness(CIMT),cystatin C(CysC)level,low density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triglyceride(TG),metal matrix proteinase-9(MMP-9),interleukin-6(IL-6)level,the incidence of adverse reactions between 2 groups were compared and the pharmacoeconomic evaluation was conducted.Results The effective rate in the study group was 89.80%,which was significantly higher than that in the control group of 88.89%.There was no statistically significant difference between the groups(P>0.05);after treatment,the hs-CPR,CIMT,and CysC of the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05);after treatment,the levels of TG,LDL-C,TC in the observation group were lower than the control group,but the difference was not statistically significant(P>0.05);after treatment,the levels of IL-6 and MMP-9 in the observation group were lower than those in the control group,but the difference was not statistically significant(P>0.05);the adverse effects of the observation group was 6.12%,compared with the control group of 6.67%,the difference was not statistically significant(P>0.05);treatment cost of the research group was 28.56 yuan,while the control group was 483.84 yuan,the treatment plan of the observation group had more pharmacoeconomic advantages.Conclusion Simvastatin capsule has a good clinical effect on atheroscleros

关 键 词：辛伐他汀胶囊 阿托伐他汀钙片 动脉粥样硬化 药物经济学 

分 类 号：R541.4[医药卫生—心血管疾病] R956[医药卫生—内科学]