莫西沙星替代异烟肼的4MRZE超短程化疗方案对初治肺结核患者肺部病灶情况及肺功能指标的影响  

Effect of 4MRZE Ultra-short Course Chemotherapy Regimen with Moxifloxacin Instead of Isoniazid on Lung Lesions and Lung Function Indexes in Newly Treated Pulmonary Tuberculosis Patients

作　　者：梁慧影 LIANG Hui-Ying(The 7th Department of Internal Medicine of Infectious Disease,Jinzhou Infectious Disease Hospital,JinZhou 121017,China)

机构地区：[1]锦州市传染病医院内七科,辽宁锦州121017

出　　处：《中国药物经济学》2021年第1期67-69,共3页China Journal of Pharmaceutical Economics

摘　　要：目的探讨莫西沙星替代异烟肼的4MRZE超短程化疗方案对初治肺结核患者肺部病灶情况及肺功能指标的影响。方法选取2017年1月至2019年1月锦州市传染病医院收治的64例初治肺结核患者作为研究对象,按随机数字表法分为观察组与对照组,各32例。对照组应用2HRZE/4HR化疗方案,观察组应用4MRZE化疗方案,比较两组的治疗效果。结果观察组治疗有效率为93.75%,与对照组90.63%相比略高,但组间差异无统计学意义(P>0.05)。治疗前,两组呼气峰流速(PEF)、肺总量(TLC)、第一秒钟用力呼气容积/用力肺活量(FEV1/FVC)水平比较差异无统计学意义(P>0.05);治疗后,两组上述肺功能指标较治疗前升高(P<0.05),但组间差异无统计学意义(P>0.05)。观察组不良反应发生率为6.25%,明显低于对照组的25.00%,差异有统计学意义(P<0.05)。结论莫西沙星替代异烟肼的4MRZE超短程化疗方案用于初治肺结核患者中价值较高,可获得与传统化疗方案等同的疗效,同时能有效改善患者肺功能,且可减少不良反应发生,提高治疗安全性。Objective To explore the effect of 4 MRZE ultra-short course chemotherapy regimen of moxifloxacin instead of isoniazid on lung lesions and pulmonary function indexes in newly treated pulmonary tuberculosis patients.Methods A total of 64 newly-treated pulmonary tuberculosis patients admitted to Department of Internal Medicine of Infectious Disease from January 2017 to January 2019 selected as the research objects and were divided into an observation group and a control group by a random number table method,with 32 cases in each group.The control group was treated with 2 HRZE/4 HR chemotherapy,and the observation group was treated with 4 MRZE chemotherapy.There were no significant between-group difference.Results The total effective rate of the observation group was 93.75%,which was slightly higher than 90.63%in the control group,but there were no significant between-group difference(P>0.05);Before treatment,there was no statistically significant difference in the levels of PEF,TLC,FEV1/FVC between the 2 groups(P>0.05).After treatment,the above-mentioned lung function indexes of the 2 groups were significantly higher than before treatment,there were no significant between-group difference(P>0.05);the adverse reaction rate of the observation group was 6.25%,which was significantly lower than that of the control group 25.00%(P<0.05).The difference was statistically significant(P<0.05).Conclusion The 4 MRZE ultra-short course chemotherapy regimen of moxifloxacin instead of isoniazid has high application value in the initial treatment of pulmonary tuberculosis patients.It can obtain the same curative effect as traditional chemotherapy regimens,effectively improve the patient’s lung function,and can reduce adverse reactions and improve treatment security.

关 键 词：莫西沙星 异烟肼 4MRZE超短程化疗方案 初治肺结核 

分 类 号：R521[医药卫生—内科学] R978.3[医药卫生—药品]