血管内皮生长因子A和B对动物脂肪沉积的调控作用研究进展  

Advances in research on the regulatory effects of vascular endothelial growth factor-A/B (VEGF-A/B) on animal fat deposition

作　　者：凌明发 赖旭敏 段晨 江青艳 王松波 LING Mingfa;LAI Xumin;DUAN Chen;JIANG Qingyan;WANG Songbo(College of Animal Sciences,South China Agricultural University/Guangdong Province Key Laboratory of Animal Nutrition Control,Guangzhou 510642,China)

机构地区：[1]华南农业大学动物科学学院/广东省动物营养调控重点实验室,广东广州510642

出　　处：《畜牧与兽医》2021年第2期137-141,共5页Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金(31972636,31790411)。

摘　　要：脂肪组织是构成动物胴体及肉品的重要组分,动物不同部位的脂肪沉积直接影响其胴体品质和肉品质。脂肪沉积的增加有两种途径:一是脂肪细胞数量的增加,即脂肪生成(adipogenesis);二是脂肪细胞体积增大,即肥大(hypertrophy)。血管内皮生长因子(vascular endothelial growth factor, VEGF)是调控血管和淋巴管生成的最重要因子之一。近年的研究发现,VEGF-A/B与机体脂肪沉积密切相关。因此,本文综述了VEGF-A/B及其受体对脂肪生成、代谢和沉积的调控作用研究进展,并对其在动物生产上的应用进行了展望,为研发调控动物不同部位脂肪沉积、提高动物胴体品质和肉品质的营养调控技术提供新的思路和科学依据。Adipose tissue is an important component of animal carcass and meat. Fat deposition at different locations in animals directly influences their carcass quality and meat quality. Increase in fat deposition can be achieved in two ways. One is the increase in adipocyte number, namely adipogenesis. The other is increase in adipocyte size, namely hypertrophy. The vascular endothelial growth factor(VEGF) is considered to be one of the most vital factors that regulate angiogenesis and lymphangiogenesis. Recent studies have demonstrated that VEGF-A/B are closely related with body fat deposition. Therefore, in this review, advances in research on the regulatory roles of VEGF-A/B and its receptors in adipogenesis, fat metabolism and fat deposition are summarized, and possible application of VEGF in animal production is proposed. This may help to provide new ideas and scientific basis for regulating animal fat deposition at different locations, and for developing nutritional control strategies to improve carcass quality and meat quality of animals.

关 键 词：血管内皮生长因子A和B 脂肪沉积 脂肪生成 脂肪代谢 

分 类 号：S811.2[农业科学—畜牧学]