心力衰竭患者静脉注射胺碘酮致急性肝损伤1例报告及临床分析  

A case report and clinical analysis of acute liver injury caused by intravenous amiodarone in a patient with heart failure

作　　者：曲婉彤 李禹慧 石妍玉 陈颖[2] QU Wantong;LI Yuhui;SHI Yanyu;CHEN Ying(College of Traditional Chinese Medicine,Changchun University of Chinese Medicine,Changchun 130117,China;Heart Disease Center,Affiliated Hospital of Changchun University of Chinese Medicine,Changchun 130021,China)

机构地区：[1]长春中医药大学中医学院,长春130117 [2]长春中医药大学附属医院心病中心,长春130021

出　　处：《长春中医药大学学报》2021年第1期149-152,共4页Journal of Changchun University of Chinese Medicine

摘　　要：1例67岁男性心力衰竭患者,入院后房颤发作。静脉注射胺碘酮后出现急性肝损伤,以谷丙转氨酶(1 885 IU·L^(-1)),谷草转氨酶(206 IU·L^(-1))升高为主。停用并应用保肝降酶药物16 d后肝功能基本恢复正常。患者1年前应用胺碘酮后无任何异常,经比较2次具体用药情况及病情,总结可能致肝损伤的病因,探讨心力衰竭合并心律失常时的临床用药选择。A 67-year-old male patient with heart failure suffered from atrial fibrillation after admission.Acute liver injury occurred after intravenous amiodarone injection was administered,which was mainly manifested by the elevation of alanine transaminase (1 885 IU·L^(-1)) and aspartate aminotransferase (206 IU·L^(-1)).The liver function basically returned to normal 16 days later after stopping amiodarone and applying the liver-protecting and enzyme-lowering drugs.The patient once used amiodarone one year ago and did not suffer from any abnormality.By comparing the exact medications and conditions of the patient under the two circumstances,the possible causes of liver injury were tentatively summarized,and clinical medication selections in the case of heart failure complicated with arrhythmia were discussed.

关 键 词：胺碘酮 肝损伤 病例报告 

分 类 号：R9[医药卫生—药学]