慢性阻塞性肺疾病并发肺动脉高压的相关因素分析  

Analysis of related factors of chronic obstructive pulmonary disease complicated with pulmonary hypertension

作　　者：张艳红 丁静[1] 冯文杰[1] 周进 ZHANG Yan-hong;DING Jing;FENG Wen-jie;ZHOU Jin(Department of lung diseases,Qinhuangdao Hospital of traditional Chinese medicine,Qinhuangdao,Hebei 066000,China)

机构地区：[1]秦皇岛市中医医院肺病科,河北秦皇岛066000

出　　处：《中国国境卫生检疫杂志》2020年第S01期58-60,69,共4页Chinese Journal of Frontier Health and Quarantine

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)并发肺动脉高压的危险因素。方法回顾性分析2017年1月至2018年12月本院收治的82例COPD患者的临床资料,采用Pearson相关性及多因素Logistic等回归分析COPD合并肺动脉高压的危险因素。结果根据单因素分析,结果显示D-二聚体、第一秒用力呼气末容积(FEV1)/预估值、C-反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子(TNF-α)、B型脑钠肽(BNP)、尿酸、氧合指数(OI)、糖类抗原125(CA125)、主肺动脉直径等均与COPD合并肺动脉高压具有相关性(P<0.05);Pearson相关性分析结果显示:FEV1/预估值、OI与肺动脉高压呈负相关,D-二聚体、CRP、BNP、尿酸、CA125与肺动脉高压呈正相关(P<0.05);多因素Logistic回归分析结果显示D-二聚体、CRP、BNP、尿酸、CA125均为COPD合并肺动脉高压的独立危险因素(OR=7.71、4.49、2.30、7.49、3.43,P<0.05)。结论肺动脉高压是COPD患者常见的并发症,其由多种因素共同影响,临床上应根据这些危险因素制定出合理有效的解决方案。Objective To investigate the risk factors of pulmonary hypertension in patients with chronic obstructive pulmonary disease(COPD).Methods the clinical data of 82 patients with COPD in our hospital from January 2017 to December 2018 were retrospectively analyzed.Pearson correlation and multivariate logistic regression were used to analyze the risk factors of COPD complicated with pulmonary hypertension.Results according to univariate analysis,the results showed that D-dimer,forced end expiratory volume in the first second(FEV1)/predicted value,C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor(TNF-α),B-type natriuretic peptide(BNP),uric acid,oxygenation index(OI),carbohydrate antigen 125(CA125),main pulmonary artery diameter were correlated with COPD complicated with pulmonary hypertension Pearson correlation analysis showed that FEV1/predicted value,OI were negatively correlated with pulmonary hypertension,D-dimer,CRP,BNP,uric acid,CA125 were positively correlated with pulmonary hypertension(P<0.05).Multivariate logistic regression analysis showed that D-dimer,CRP,BNP,uric acid,CA125 were independent risk factors of COPD with pulmonary hypertension(or=7.71,4.49,2.30,7.49,3.43,P<0.05)。Conclusion pulmonary hypertension is a common complication of COPD patients,which is affected by many factors.We should make reasonable and effective solutions according to these risk factors.

关 键 词：慢性阻塞性肺疾病 肺动脉高压 相关因素 

分 类 号：R563[医药卫生—呼吸系统]