肝片形吸虫感染宿主细胞免疫的研究进展  

Research progress on host cell immunity in Fasciola hepatica infection

作　　者：张宝月 宋正已 ZHANG Bao-yue;SONG Zheng-yi(Medical School,Kunming University of Science and Technology,Kunming 650500,China;Department of Gastroenterology,the First People's Hospital of Yunnan Provincey the Affiliated Hospital of Kunming University of Science and Technology,Kunming 650032,China)

机构地区：[1]昆明理工大学医学院,昆明650500 [2]云南省第一人民医院消化内科/昆明理工大学附属医院,昆明650032

出　　处：《中国寄生虫学与寄生虫病杂志》2021年第1期107-111,119,共6页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然科学基金(81760110)。

摘　　要：肝片形吸虫病是一种危害严重的人兽共患病,肝片形吸虫主要感染反刍动物及包括人类在内的哺乳动物,是一个严重威胁健康、影响经济发展的公共卫生问题。目前治疗肝片形吸虫病的药物少、疗效有限。大量研究表明,肝片形吸虫受宿主免疫应答的调控,本文对肝片形吸虫病的发病机制、肝片形吸虫主要参与诱导的几种机体细胞免疫反应及相关的研究进展进行综述.以期为肝片形吸虫病的临床治疗提供资料。Fascioliasis hepatica is a devastating zoonotic disease. Fasciola hepatica mainly infects ruminants and mammals including humans. Fascioliasis hepatica has become a public health problem that poses severe threats to human health and economic development. Currently, the treatment of fascioliasis hepatica is challenged by limited medication choice and unsatisfactory curative effect. Extensive studies have shown that F. hepatica infection is regulated by the immune response of the host. In this review, we summarize the pathogenesis of fascioliasis hepatica,several cellular immune responses induced by F. hepatica and related research progress, in order to provide information for the clinical treatment of fascioliasis hepatica.

关 键 词：肝片形吸虫 发病机制 细胞免疫 

分 类 号：R532.29[医药卫生—内科学]