Bi_(2)O_(3)/ZnO nanocomposite:Synthesis,characterizations and its application in electrochemical detection of balofloxacin as an antibiotic drug  

作　　者：Sana Ansari M.Shahnawaze Ansari Soami P.Satsangee Rajeev Jain 

机构地区：[1]Department of Chemistry,Dayalbagh Educational Institute,Dayalbagh,Agra,282005,India [2]Center of Nanotechnology,King Abdulaziz University,Jeddah,21589,Saudi Arabia [3]Advanced Membrane Technology Research Centre(AMTEC),Universiti Teknologi Malaysia,81310,Skudai,Johor,Malaysia [4]School of Chemical and Energy Engineering,Universiti Teknologi Malaysia,81310,Skudai,Johor,Malaysia [5]School of Studies in Chemistry,Jiwaji University,Gwalior,474011,India

出　　处：《Journal of Pharmaceutical Analysis》2021年第1期57-67,共11页药物分析学报（英文版）

摘　　要：In the present work,a chemically modified electrode has been fabricated utilizing Bi_(2)O_(3)/ZnO nanocomposite.The nanocomposite was synthesized by simple sonochemical method and characterized for its structural and morphological properties by using XRD,FESEM,EDAX,HRTEM and XPS techniques.The results clearly indicated co-existence of Bi_(2)O_(3) and ZnO in the nanocomposite with chemical interaction between them.Bi_(2)O_(3)/ZnO nanocomposite based glassy carbon electrode(GCE)was utilized for sensitive voltammetric detection of an anti-biotic drug(balofloxacin).The modification amplified the electroactive surface area of the sensor,thus providing more sites for oxidation of analyte.Cyclic and square wave voltammograms revealed that Bi_(2)O_(3)/ZnO modified electrode provides excellent electrocatalytic action towards balofloxacin oxidation.The current exhibited a wide linear response in concentration range of 150e1000 nM and detection limit of 40.5 nM was attained.The modified electrode offered advantages in terms of simplicity of preparation,fair stability(RSD 1.45%),appreciable reproducibility(RSD 2.03%)and selectivity.The proposed sensor was applied for determining balofloxacin in commercial pharmaceutical formulations and blood serum samples with the mean recoveries of 99.09% and 99.5%,respectively.

关 键 词：ZnO nanoparticles Chemically modified electrode VOLTAMMETRY Drug analysis 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置] R969.1[自动化与计算机技术—控制科学与工程]