COPD急性加重期患者血清suPAR、HNP1-3水平变化及意义  

Changes and clinical significance of serum levels of suPAR and HNP1-3 in patients with acute exacer⁃bation of chronic obstructive pulmonary disease

作　　者：白玉霞 黄少祥[1] 刘静[1] 马丽[1] 刘鹏[1] BAI Yuxia;HUANG Shaoxiang;LIU Jing;MA Li;LIU Peng(Tianjin Fifth Central Hospital,Tianjin 300450,China)

机构地区：[1]天津市第五中心医院,天津300450

出　　处：《山东医药》2021年第7期28-31,共4页Shandong Medical Journal

基　　金：天津市自然科学基金项目(16JCMSJC11638)。

摘　　要：目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血清可溶性尿激酶型纤溶酶原激活物受体(su‑PAR)、人中性粒细胞肽1-3(HNP1-3)水平变化及意义。方法选择90例AECOPD患者(AECOPD组)、57例稳定期COPD患者(COPD组)及50例健康志愿者(对照组)。采用酶联免疫吸附试验检测血清suPAR、HNP1-3水平,Master Screen肺功能仪检测肺功能,根据AECOPD患者临床结局分为死亡组和存活组,分析血清suPAR、HNP1-3水平与AECOPD患者肺功能和预后的关系。结果AECOPD组血清suPAR、HNP1-3水平高于COPD组和对照组(P均<0.05),第1秒用力呼气容积(FEV_(1))、FEV_(1)与用力肺活量(FVC)比值(FEV_(1)/FVC)、FEV_(1)占预计值百分数(FEV_(1)%pred)低于COPD组和对照组(P均<0.05)。死亡组血清suPAR、HNP1-3水平均高于存活组(P<0.05)。Pearson相关性分析结果显示,AECOPD患者血清suPAR水平与FEV_(1)、FEV_(1)/FVC、FEV_(1)%pred呈负相关(r分别为-0.519、-0.635、-0.664,P均<0.05),HNP1-3水平与FEV_(1)、FEV_(1)/FVC、FEV_(1)%pred呈负相关(r分别为-0.537、-0.595、-0.603,P均<0.05)。受试者工作特征(ROC)曲线分析结果显示,血清suPAR、HNP1-3、suPAR+HNP1-3预测AECOPD患者预后的曲线下面积(AUC)分别为0.682、0.785、0.891,灵敏度分别为63.64%、72.73%、90.91%,特异度分别为73.68%、77.63%、92.11%。结论AECOPD患者血清suPAR、HNP1-3水平均升高;二者可作为AECOPD病情评估、预后预测的辅助指标。objective To investigate the changes and clinical significance of serum levels of soluble urokinase plasminogen activator receptor(suPAR)and human neutrophil peptide 1-3(HNP1-3)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Ninety cases of AECOPD patients(AECOPD group),57 cases of COPD patients(COPD group)and 50 healthy volunteers(control group)were selected.Serum levels of suPAR and HNP1-3 were detected by enzyme-linked immunosorbent assay,and lung function was detected by Master Screen lung function analyzer.According to the clinical outcome,AECOPD patients were divided into the death group and survival group.We analyzed the relationships between serum suPAR and HNP1-3 levels and lung function and prognosis of AECOPD patients.Results The serum levels of suPAR and HNP1-3 in the AECOPD group were higher than those in the COPD group and control group(all P<0.05),and the forced expiratory volume in the first second of exhalation(FEV_(1)),the ratios of FEV_(1) and forced vital capacity(FVC)(FEV_(1)/FVC),and the percentage of FEV_(1) in the predicted value(FEV_(1)%pred)were lower than those in the COPD group and control group(all P<0.05).The serum levels of suPAR and HNP1-3 in the death group were higher than those in the survival group(both P<0.05).Pearson correlation analysis results showed that the serum level of suPAR in the AECOPD patients was negatively correlated with FEV_(1),FEV_(1)/FVC and FEV_(1)%pred(r=-0.519,-0.635,-0.664,all P<0.05),and the serum level of HNP1-3 was negatively correlated with FEV_(1),FEV_(1)/FVC,and FEV_(1)%pred(r=-0.537,-0.595,-0.603,all P<0.05).The area under the curve(AUC)of su‑PAR,HNP1-3 and suPAR+HNP1-3 in predicting the prognosis of AECOPD patients was 0.682,0.785,and 0.891 respectively,and the sensitivities were 63.64%,72.73%,and 90.91%,respectively,and the specificities were 73.68%,77.63%,and 92.11%,respectively.Conclusion The serum levels of suPAR and HNP1-3 in AECOPD patients all increase,and the levels of suPAR and HNP1-3 are clo

关 键 词：慢性阻塞性肺疾病急性加重期 可溶性尿激酶型纤溶酶原激活物受体 肺功能 人中性粒细胞肽1-3 病情评估 预后 

分 类 号：R563[医药卫生—呼吸系统]