非编码RNA在阿霉素心脏毒性中的研究进展  

Research progress of non-coding RNA in doxorubicin-induced cardiotoxicity

作　　者：陆文强 池菊芳[2] 郭航远 Li Wenqiang;Chi Jufang;Guo Hangyuan(Zhejiang University School of Medicine,Hangzhou 310000,China;Department of Cardiology,Shaoxing People's Hospital(Shaoxing Hospital,Zhejiang University),Shaoxing 312000,China)

机构地区：[1]浙江大学医学院,杭州310000 [2]浙江省绍兴市人民医院(浙江大学绍兴医院)心内科,312000

出　　处：《中国医师杂志》2021年第2期310-313,共4页Journal of Chinese Physician

基　　金：国家自然科学基金(81873120);浙江省自然科学基金联合基金项目(LBY20H020001);浙江省医药卫生科技计划项目(2018KY172)。

摘　　要：阿霉素是一种有效的蒽环类化疗药物,被广泛应用于各种恶性肿瘤的单独或联合化疗。但阿霉素所造成的心脏毒性在一定程度上限制了其临床应用。尽管有大量的研究投入,目前仍未找到合适的靶点能够在保障化疗效果的同时降低阿霉素所致心肌损伤。近年来研究发现非编码RNA与阿霉素心脏毒性有关,进一步阐释两者的相互关系或将为阿霉素所致心脏毒性的诊断、预防及治疗提供新思路。Doxorubicin is an effective anthracycline chemotherapeutic drug,which is widely used in single or combined chemotherapy for various malignant tumors.However,the cardiotoxicity caused by doxorubicin has limbed its clinical application.Despite a large amount of research investment,no suitable target has been found to reduce cardiotoxicity caused by doxorubicin while guaranteeing the effect of chemotherapy.Recent studies have found that non-coding RNA is related to doxorubicin-induced cardiomyopathy.Further explaining the relationship between the two may provide new strategies for the diagnosis,prevention and treatment of doxorubicin-induced cardiotoxicity.

关 键 词：心脏毒性 阿霉素 非编码RNA 

分 类 号：R969[医药卫生—药理学]