PFNA术后应用动物骨多肽类药物促进骨折愈合的临床疗效研究  

Clinical efficacy of animal bone peptides in promoting fracture healing after PFNA operation

作　　者：赵晓明 苏晨晨 娄啸霄 张银刚[1] ZHAO Xiao-ming;SU Chen-chen;LOU Xiao-xiao;ZHANG Yin-gang(Department of Orthopedics,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi 710061,China)

机构地区：[1]西安交通大学第一附属医院骨科,陕西西安710061 [2]延安市中医院运动医学科,陕西延安716000

出　　处：《中华全科医学》2021年第3期347-350,共4页Chinese Journal of General Practice

基　　金：国家自然科学基金(81371987)。

摘　　要：目的探究动物骨多肽类药物在骨折愈合方面对于行股骨近端防旋髓内钉术(proximal femoral nail antirotation,PFNA)的骨质疏松性股骨粗隆间骨折患者的临床疗效影响。方法选取2018年12月—2019年6月西安交通大学第一附属医院骨科收治的104例股骨粗隆间骨折患者,采用随机数字表法分为对照组和观察组,每组52例。2组患者均行PFNA,观察组术后应用动物骨多肽注射液继续治疗,对照组术后给予常规药物治疗以进行对比,比较2组患者术后骨折临床愈合时间、疼痛评分、髋关节功能评分、手术优良率及骨矿物质密度改善,并记录治疗过程中并发症发生率。结果104例病例均得到随访,观察组与对照组相比,术后骨折临床愈合时间明显缩短[(11.37±1.35)周vs.(12.85±1.76)周],术后疼痛症状的缓解程度[(0.21±0.11)vs.(0.83±0.13)]及髋关节功能恢复程度[(86.35±10.51)vs.(75.61±11.32)]也优于对照组,同时,不同部位骨密度测量值也较对照组有所提高,术后并发症的发生率也显著降低(3.8%vs.7.7%),差异具有统计学意义(均P<0.05)。结论动物骨多肽类注射液能有效地促进骨折的愈合,同时能够有效消肿止痛,缓解患者的病痛,加快术后髋关节的功能恢复,并能有效降低术后再骨折等不良并发症的发生率,是股骨粗隆间骨折行PFNA固定术后的一种良好的补充用药,值得在推广应用。Objective To explore the effect of animal bone polypeptide injection on the postoperative fracture healing of senile osteoporosis intertrochanteric fracture after proximal femoral nail antirotation(PFNA).Methods A total of 104 senile osteoporotic femoral intertrochanteric fractures admitted to the Department of Orthopedics,the First Affiliated Hospital of Xi’an Jiaotong University from December 2018 to June 2019 were selected.According to the method of random number table,all the patients were divided into the control group(52 cases)and the observation group(52 cases).PFNA surgery was performed in both groups.Patients in the observation group used animal bone polypeptide after surgery,while patients in the control group were treated with conventional basic drug after surgery for comparison.Postoperative pain relief(VAS score),hip fracture healing,postoperative joint function recovery(Harris score),excellent and good fracture healing rate and bone mineral density deposition improvement were compared between the two groups.Adverse complications during follow-up treatment were recorded and the rate was calculated.Results All 104 cases were followed up.Compared with the control group,the clinical healing time of postoperative fracture in the observation group was obviously shorter[(11.37±1.35)weeks vs.(12.85±1.76)weeks],the degree of relief of postoperative pain symptoms[(0.21±0.11)vs.(0.83±0.13)]and the degree of functional recovery of hip joint[(86.35±10.51)vs.(75.61±11.32)]in the observation group were also better than those in the control group.Meanwhile,the bone mineral density of different parts in the observation group was higher than that in the control group,and the incidence of postoperative complications was also significantly lower(3.8%vs.7.7%),all P<0.05).Conclusion Animal bone polypeptide drugs can effectively promote fracture healing,reduce swelling and pain,facilitate the postoperative rehabilitation of hip function,and effectively decrease adverse complications during follow-up treatment such

关 键 词：动物骨多肽 股骨粗隆间骨折 骨质疏松 内固定 股骨近端防旋髓内钉 

分 类 号：R683.42[医药卫生—骨科学] R687.33[医药卫生—外科学]