皮肤再生医疗技术对肛瘘术后创面愈合的影响研究  

Study on the effect of skin regeneration medical technology on wound healing after anal fistula operation

作　　者：兰海生 李明尚 黄许森[1] 黄海舸[1] 岑小宁 钟丽华 LAN Haisheng;LI Mingshang;HUANG Xusen;HUANG Haige;CEN Xiaoning;ZHONG Lihua(The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi,China;Youjiang Medical University for Nationalities, Baise 533000, Guangxi,China)

机构地区：[1]右江民族医学院附属医院,广西百色533000 [2]右江民族医学院,广西百色533000

出　　处：《现代中西医结合杂志》2021年第7期709-713,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：国家自然科学基金资助项目(81860852);广西自然科学基金资助项目(2017JJA140417z)。

摘　　要：目的探讨皮肤再生医疗技术对肛瘘术后创面愈合的影响。方法将2019年3—7月在右江民族医学院附属医院肛肠科住院治疗的60例肛瘘患者随机分成2组,对照组30例术后创面采用传统方法处理,实验组30例术后创面采用皮肤再生医疗技术处理,观察2组术后第3,7,14,21天创面分泌物、肉芽组织以及肛门疼痛情况,检测2组术前及术后第1,7,14天血清白细胞介素-4(IL-4)、白细胞介素-6(IL-6)水平,比较2组术后第3,14,21天创面愈合情况和创面完全愈合时间。结果实验组术后第14,21天创面分泌物评分,术后第3,7,14,21天肉芽组织评分,术后第7,14,21天疼痛评分均明显低于同期对照组(P均<0.05)。术后2组血清IL-4和IL-6水平均呈现先升高后降低趋势;实验组术后第1,7天血清IL-4水平均明显高于同期对照组(P均<0.05),术后第14天IL-4水平明显低于对照组(P<0.05);实验组术后第1,7,14天血清IL-6水平均明显低于同期对照组(P均<0.05)。实验组术后第14,21天创面面积均明显小于同期对照组(P均<0.05),创面愈合率均明显高于同期对照组(P均<0.05);实验组创面完全愈合时间明显短于对照组(P<0.05)。结论皮肤再生医疗技术能有效减少肛瘘术口渗出,减轻疼痛,调控炎症反应,从而促进术后创面愈合,缩短创面愈合时间。Objective It is to explore the effect of skin regeneration medical technology on wound healing after anal fistula surgery.Methods Sixty patients with anal fistula who were hospitalized in the Anorectal Department of the Affiliated Hospital of Youjiang Medical University for Nationalities from March to July 2019 were randomly divided into two groups.30 patients in the control group were treated with traditional methods,and 30 patients in the experimental group were treated with skin regeneration medical technology.The wound secretions,granulation tissue and anal pain on the 3rd,7th,14th,and 21st days after the operation were observed in the 2 groups,the levels of serum interleukin-4(IL-4)and IL-6 were detected before the operation and on the 1st,7th and 14th day after the operation in the 2 groups.The postoperative wound healing on the 3rd,14th,and 21st day and the wound complete healing time were compared between the 2 groups.Results The wound secretion scores on the 14th and 21st days after the operation,the granulation tissue scores on the 3rd,7th,14th and 21st days after the operation,and the pain scores on the 7th,14th and 21st days after the operation in the experiment group were significantly lower than those of the control group at the same time(P<0.05).The levels of serum IL-4 and IL-6 in the two groups after surgery showed a trend of first increasing and then decreasing;the levels of serum IL-4 in the experimental group were significantly higher than those in the control group on the 1st and 7th days after surgery(all P<0.05),but the level on the 14th day after operation were significantly lower than that in the control group(P<0.05);the levels of serum IL-6 in the experimental group were significantly lower than those in the control group on the 1st,7th,and 14th days after operation(all P<0.05).The wound area of the experimental group was significantly smaller and the wound healing rate was significantly higher than that of the control group on the 14th and 21st day after operation(P<0.05);the wound hea

关 键 词：皮肤再生医疗技术 肛瘘 创面愈合 

分 类 号：R657.16[医药卫生—外科学]