氟喹诺酮抗生素与主动脉瘤/夹层发生和发展的关系  

Relationship between fluoroquinolone antibiotics and the occurrence and development of aortic aneurysm/aortic dissection

作　　者：张波[1] 王文艳 陈蒙华[1] ZHANG Bo;WANG Wenyan;CHEN Menghua(Intensive Care Unit,The Second Affiliated Hospital of Guangxi Medical University,Nanning,530007,China)

机构地区：[1]广西医科大学第二附属医院重症医学科,南宁530007

出　　处：《临床心血管病杂志》2020年第12期1083-1087,共5页Journal of Clinical Cardiology

摘　　要：随着氟喹诺酮类抗生素在临床上运用愈加广泛,其对主动脉瘤及夹层的影响逐渐被关注。越来越多的证据表明,氟喹诺酮类抗生素的使用与主动脉瘤/夹层发生、发展的风险呈正相关。患有主动脉病或处于主动脉病高危因素的人群暴露于氟喹诺酮类抗生素会增加发病风险,而这一潜在风险尚未在临床治疗中引起足够的重视。本文回顾氟喹诺酮类药物的临床运用及与主动脉病的相关性,总结其影响机制,针对临床目前的现状提出必要的警示,以及未来可能的研究方向。As fluoroquinolones are increasingly widely used in clinics,more and more attention is being paid to their effects on aortic aneurysm and dissection.There is evidence that the use of fluoroquinolone antibiotics is positively correlated with the occurrence and development of aortic aneurysm and dissection.More importantly,exposure to fluoroquinolone antibiotics in patients who still have aortic diseases or are under high risk of aortic diseases will increase the risk,which has not been paid enough attention in clinical practice.Therefore,this paper examines the clinical application of fluoroquinolones and its correlation with aortic disease and summarizes its mechanism.Finally,the necessary warnings for the current clinical situation and the possible future research direction are proposed.

关 键 词：氟喹诺酮 主动脉瘤 细胞外基质 平滑肌细胞 基质金属蛋白酶 

分 类 号：R543.1[医药卫生—心血管疾病]