我国近十年手足口病病原谱及分子流行病学研究进展  

Progress in pathogenic spectrum and molecular epidemiology of hand,foot and mouth disease in China in the last decade

作　　者：张萌 陈祥鹏 谢正德 Zhang Meng;Chen Xiangpeng;Xie Zhengde(Beijing Key Laboratory of Pediatric Respiratory Infectious diseases,Key Laboratory of Major Diseases in Children,Ministry of Education,National Clinical Research Center for Respiratory Diseases,Research Unit of Critical Infection in Children,Chinese Academy of Medical Sciences,2019RU016,Laboratory of Infection and Virology,Beijing Pediatric Research Institute,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院,北京市儿科研究所感染与病毒研究室,中国医学科学院儿童危重感染诊治创新单元,国家呼吸系统疾病临床医学研究中心,儿科重大疾病研究教育部重点实验室,儿童呼吸道感染性疾病研究北京重点实验室,北京100045

出　　处：《中华实验和临床病毒学杂志》2020年第6期660-664,共5页Chinese Journal of Experimental and Clinical Virology

基　　金：国家科技重大专项(2018ZX10201002-003-009,2017ZX10104001-005-010);北京市自然科学基金(7184208);国家自然科学基金(81971922);北京市自然科学基金-海淀原始创新联合基金(L192014);首都医科大学基础临床科研合作课题(17JL11)。

摘　　要：手足口病(hand, foot, and mouth disease, HFMD)是世界范围内流行的一种由肠道病毒感染引起的急性传染性疾病。引起中国大陆HFMD的主要病原为肠道病毒A组71型(enterovirus A71,EV-A71)、柯萨奇病毒A组16型(Coxsackievirus A16,CV-A16)和柯萨奇病毒A组6型(coxsackievirus A6,CV-A6),不同时期不同地区HFMD的病原谱存在差异。近年我国HFMD病原谱发生了较大的变化,这一方面与肠道病毒的流行规律有关,另一方面也可能受近年EV-A71疫苗应用的影响。本文对中国近十年来HFMD的流行状况、病原谱变化及分子流行病学进行综述。Hand,foot,and mouth disease(HFMD)is an acute infectious disease caused by enteroviruses existing worldwide.Enterovirus 71(EV-A71),Coxsackievirus A16(CV-A16)and Coxsackievirus A6(CV-A6)are the major pathogens of HFMD in the mainland of China.The pathogenic spectrum of HFMD has changed significantly in China.It is related to the epidemic pattern of enterovirus and may also be affected by the application of EV-A71 vaccine.This review focuses mainly on the epidemic patterns,the pathogenic spectrum and the molecular epidemiology of HFMD in the mainland of China.

关 键 词：手足口病 病原谱 分子流行病学 

分 类 号：R181.3[医药卫生—流行病学] R725.1[医药卫生—公共卫生与预防医学]