儿童人博卡病毒1型感染研究进展  

Research progress in human bocavirus 1 infections in children

作　　者：廖静[1] 臧娜[1] 刘恩梅[1] Liao Jing;Zang Na;Liu Enmei(Department of Respiratory Diseases,Children′s Hospital of Chongqing Medical University Ministry of Education National Center for Clinical Medical Research on Child Health and Diseases,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院呼吸科,国家儿童健康与疾病临床医学研究中心,400014

出　　处：《中华实验和临床病毒学杂志》2020年第6期677-682,共6页Chinese Journal of Experimental and Clinical Virology

摘　　要：人博卡病毒1型(human bocavirus 1,HBoV1)是导致儿童重症下呼吸道感染重要的病毒病原之一,可引起肺炎与毛细支气管炎。HBoV1 DNA可在急性感染患者鼻咽分泌物中持续存在,建立潜伏感染,促进肺纤维化发生,HBoV1致病机制尚不明确,准确诊断HBoV1感染不能仅基于定性PCR,须结合定量PCR和血清学检查。本文探讨HBoV1病毒学特征、流行病学特征、HBoV1致病机制、HBoV1感染与疾病、检测与诊断等方面做全面总结,并展望其未来的主要研究方向。Human bocavirus 1(HBoV1)is one of the most important pathogenic viruses in children with severe lower respiratory tract infections,which can cause pneumonia and bronchiolitis.HBoV1 DNA can persist in nasopharyngeal secretions after acute infection for several months,establish latent infection to promote the occurrence of pulmonary fibrosis.Consequently,mere qualitative PCR is not an adequate method for diagnosing HBoV1 infections accurately.It must be combined with quantitative PCR and serology.This review makes a comprehensive summary on the virological characteristics,epidemiological characteristics,pathogenesis and diseases caused by HBoV1 infections,detection and diagnosis of HBoV1,and looks forward to its main further research direction.

关 键 词：人博卡病毒1型 流行病学 致病机制 检测 潜伏 

分 类 号：R725.6[医药卫生—儿科]