细菌和病毒感染导致血瘀证的机制及血必净的多靶点治疗作用  

Mechanism of blood stasis sy ndrome induced by bacteria and virus infection and multi-target treatment effect of Xuebijing

作　　者：王萍 郑蕊 王朋倩 钟长鸣 王建勋 商洪才[2] Wang Ping;Zheng Rui;Wang Pengqian;Zhong Changming;Wang Jianxun;Shang Hongcai(School of Life Science,Beijing University of Chinese Medicine,Bejing 102400,China;Dongzhimen Hospital,Beijing,University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学生命科学学院,北京102400 [2]北京中医药大学东直门医院,北京100700

出　　处：《中国中西医结合急救杂志》2020年第6期762-765,共4页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：18-19北京市双一流人才高层次匸建勋科研团队科研经费项目(1000041510155)。

摘　　要：细菌和病毒是造成人体感染性疾病最常见的病原微生物,两者导致的疾病临床症状和严重程度差异很大.严重感染过程中,机体出现氧化应激、免疫失调及凝血功能紊乱,且各系统间相互作用,级联放大,最终导致机体微循环功能障碍,组织器官缺血缺氧,若得不到及时有效的治疗,则容易发展为重症肺炎、脓毒症,甚至死亡.凝血功能紊乱及微循环障碍属于中医"血瘀证"范畴,具有活血化瘀作用的血必净注射液在治疗重症肺炎和脓毒症中发挥了多靶点的作用,其机制可能与阻断氧化应激、免疫失衡与凝血紊乱之间的"交汇作用",遏制三者相互促进的恶性循环有关.本文从细菌和病毒等感染诱发氧化应激损伤、免疫功能失衡、凝血功能紊乱和血必净注射液的多靶点治疗作用4个方面进行综述.Bacteria and virus are the most common pathogenic microbes of human infectious disease.The clinical symptoms and severity of disease caused by bacteria and virus differ greatly among patients.Oxidative stress,immune dysfunction and coagulation disorder may occur in organisms during severe infection.The interaction among various systems and the cascade-amplifieation ffcts result in microcirculation dysfunction and lead to ischemia and hypoxia of tissues and organs.Under the above situation,if no timely and effective treatment can be applied,it could easily develop into severe pneumonia,sepsis,and even death.Coagulation disorder and microeirculation dyfunction belong to the category of"blood stasis syndrome"in traditional Chinese medicine.Xuebijing injection,which has the function of promoting blood circulation and removing blood stasis,has played a multi-target role in the treatment of severe pneumonia and sepsis.The mechanism may be related to blocking the"crosstalk"among oxidative stress,immune dysfunction and coagulation disorder,leading to curbing the vicious cirele of mutual promotion.This article reviews the four aspeets such as oxidative stress injury,immune function imbalance,blood coagulation disorders induced by bacterial and viral infection,and muli-larget therapeutie effect of Xuebijing injection.

关 键 词：细菌 病毒 感染 血瘀证 血必净注射液 多靶点作用 

分 类 号：S85[农业科学—兽医学]