天然生物碱类镇痛成分的研究进展  

Research progress of natural alkaloids with analgesic activity

作　　者：王玲燕 夏桂阳 夏欢 王亚男 卫晓红 田贵华[1] 林生 WANG Ling-yan;XIA Gui-yang;XIA Huan;WANG Ya-nan;WEI Xiao-hong;TIAN Gui-hua;LIN Sheng(Key laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]北京中医药大学东直门医院中医内科学教育部和北京市重点实验室,北京100700 [2]中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室,北京100050

出　　处：《中国中药杂志》2020年第24期5829-5839,共11页China Journal of Chinese Materia Medica

基　　金：北京市自然科学基金项目(JQ18026);国家自然科学基金项目(81773589,81522050,82073978)。

摘　　要：疼痛是机体对有害刺激的一种保护性防御反应,长期疼痛不仅严重影响患者的躯体,给病人带来极大的痛苦,也给病人家庭和社会带来巨大的经济负担,已成为当今困扰人类健康最严重的问题之一。目前临床常用止痛药为阿片类和非甾体抗炎药(NSAIDs)等,但易造成多种不良反应或存在成瘾性的风险。寻找和开发更安全更有效的新型镇痛药物,已成为医学领域研究的热点及难点。生物碱是广泛存在于动、植物及微生物中的一类天然活性成分,多种生物碱已经明确具有较好的镇痛作用,如以吗啡为代表的阿片类镇痛药物,以及延胡索、附子等传统镇痛中药主要镇痛活性成分均为生物碱类成分。该文综述了已发现的具有镇痛活性的天然生物碱类成分的研究进展,以期为基于天然产物的镇痛药物的研发提供参考和借鉴。Pain is a protective defense response of the body to harmful stimuli.Long-term pain not only seriously affects the body of the patient and brings great pain to the patient,but also brings huge economic burden to the patient′s family and society.It has become one of the most serious problems affecting human health.At present,opioids and non-steroidal anti-inflammatory drugs(NSAIDs)are commonly used as painkillers,but they tend to cause a variety of adverse reactions or risk of addiction.To find and develop new analgesic drugs,which are safer and more effective,has become the hot spot and difficulty in medical research.A variety of alkaloids derived from terrestrial plants,microorganisms,marine organisms and fungi have been an important source of clinical analgesic medicines.Various alkaloids have been proved to have good analgesic effects,such as morphine and the related to opioids,the main analgesic active components from Corydalis Rhizoma and Aconiti Lateralis Radix Praeparata.Here we summarized the research progress of natural alkaloids with analgesic activity,in order to provide reference for the research and development of analgesic drugs based on natural products.

关 键 词：天然产物 生物碱 镇痛 

分 类 号：R284[医药卫生—中药学]