新生儿肠道病毒感染86例临床分析  

Clinical analysis of 86 cases with neonatal enterovirus infection

作　　者：吴运芹[1] 高喜容[1] 詹敏 谭李红[1] Wu Yunqin;Gao Xirong;Zhan Min;Tan Lihong(Department of Neonatology,Hu nan Children's Hospital,Changsha 410007,China)

机构地区：[1]湖南省儿童医院新生儿科,长沙410007

出　　处：《中国小儿急救医学》2020年第12期925-928,共4页Chinese Pediatric Emergency Medicine

基　　金：湖南省科技厅重点研发项目(2017SK2154)。

摘　　要：目的分析86例肠道病毒感染新生儿的临床特点。方法回顾性分析2019年5月至7月我院新生儿科收治的肠道病毒感染新生儿。分析患儿的实验室检查数据及临床资料。结果 86例新生儿肠道病毒感染患儿,其中男59例,女27例;足月儿75例,早产儿11例;早期新生儿17例,晚期新生儿69例。82例治愈出院,4例死亡。首发症状包括发热75例(75/86,87.2%),黄疸50例(50/86,58.1%),呼吸困难17例(17/86,19.8%),皮疹9例(9/86,10.5%),腹泻9例(9/86,10.5%),腹胀8例(8/86,9.3%),呕吐5例(5/86,5.8%),抽搐2例(2/86,2.3%)。重症患儿最多见为凝血功能异常(17/86,19.8%),肝功能损害(11/86,12.8%)和心肌损伤(9/86,10.5%)。6例患儿合并出血-肝炎综合征,其中4例死亡。出血肝炎综合征组与普通组患儿比较,日龄≤7 d、呼吸困难、腹胀、凝血功能异常、肝功能损害、心肌损害、低蛋白血症、降钙素原升高、血小板下降、死亡比例显著增高,差异有统计学意义(P<0.05)。结论新生儿肠道病毒感染临床表现不同,早期新生儿更易发生重症肠道病毒感染。合并出血-肝炎综合征的患儿病情凶险,临床需高度重视。Objective:To analyze the clinical characteristics of 86 neonates with enterovirus infection.Methods:A retrospective analysis was performed in neonates with enterovirus infection in Neonatology Department at our hospital from May 2019 to July 2019.Clinical characteristics and laboratory examinations of the neonates were collected and analyzed.Results:There were 86 cases of neonatal enterovirus infection, including 59 males and 27 females;75 full-term infants and 11 premature infants;17 early-onset neonates and 69 late-onset neonates;82 cases were cured and discharged, and four cases died.The first clinic symptoms included fever (75/86, 87.2%), jaundice (50/86, 58.5%), dyspnea (17/86, 19.8%), rash (9/86, 10.5%), diarrhea (9/86, 10.5%), abdominal distension (8/86, 9.3%), vomiting (5/86, 5.8%), and convulsion (2/86, 2.3%). Coagulation dysfunction (17/86, 19.8%), liver dysfunction (11/86, 12.8%), and myocardial damage (9/86, 10.5%) were founded in severe cases.Six infants had hepatic necrosis with coagulopathy (HNC), and four of them died.Compared with control group, earlier age of onset(<7 days), dyspnea, abdominal distention, coagulation dysfunction, liver function damage, myocardial damage, hypoproteinemia, procalcitonin increased, decreased platelets and death rate were significantly higher than those in infants from HNC group ( P<0.05). Conclusion:Neonatal enterovirus infection have diverse manifestations.Infants with HNC have high mortality and are needed to be monitored closely.

关 键 词：新生儿 肠道病毒感染 临床分析 

分 类 号：R722.1[医药卫生—儿科]