补充Omega-3多不饱和脂肪酸对2型糖尿病患者血糖水平影响的meta分析  

EFFECT OF OMEGA-3 POLYUNSATURATED FATTY ACIDS SUPPLEMENTATION ON GLUCOSE CONTROL IN PATIENTS WITH TYPE 2 DIABETES MELLITUS:A META-ANALYSIS

作　　者：宋欣月 张英春 刘宇鹏 单毓娟 SONG Xin-yue;ZHANG Ying-chun;LIU Yu-peng;SHAN Yu-juan(Department of Food Science and Engineering,School of Chemical Engineering and Chemistry,Harbin Institute of Technology,Harbin 150001;School of Public Health and Management,Wenzhou Medical University,Wenzhou,325000,China)

机构地区：[1]哈尔滨工业大学化工与化学学院食品科学与工程系,哈尔滨150001 [2]温州医科大学公共卫生与管理学院,温州3250000

出　　处：《营养学报》2020年第5期449-457,共9页Acta Nutrimenta Sinica

基　　金：中国营养学会达能营养中心研究基金(No.DIC2016-05)。

摘　　要：目的评估补充omega-3多不饱和脂肪酸(omega-3 PUFA)对2型糖尿病(T2DM)患者空腹血糖和糖化血红蛋白的影响。方法 :检索PubMed,Elsevier,Cochrane Library数据库,搜集1988-2019年符合条件的随机对照试验(RCT)。数据以标准化均数差(SMD)及95%置信区间(95%CI)表示,应用Rveman5.3统计软件,采用固定效应模型进行分析。结果本文共纳入26例RCT试验。在合并分析中,与对照组相比补充omega-3 PUFA对T2DM患者空腹血糖(FBG)(SMD=0.09,95%CI:-0.01,0.20;12=57%)以及糖化血红蛋白(HbA1c)(SMD=0.01,95%CI:0.10,-0.11;I2=48%)无显著影响。在FBG亚组分析中发现,T2DM患者血糖基线水平、补充omega-3 PUFA时间均显著影响T2DM患者FBG水平;在HbA1c亚组分析中,T2DM患者HbA1c基线水平、日补充omega-3 PUFA剂量以及干预时间均对T2DM患者HbA1c水平具有显著影响。结论长期膳食补充omega-3 PUFA可能会对T2DM患者空腹血糖水平起到积极作用,但需要根据自身血糖及HbA1c基线水平持续12 w以上补充合适剂量的Omega-3 PUFA。Objective To evaluate the effect of omega-3 polyunsaturated fatty acids(Omega-3 PUFA) supplementation on blood glucose/glycated hemoglobin in patients with type 2 diabetes mellitus(T2 DM).Methods PubMed,Elsevier,and Cochrane Library databases were searched from 1988 to 2019 for randomized controlled trials(RCT) investigating the effect of omega-3 PUFA supplementation on glucose control in patients with type 2 diabetes.Data were pooled and analyzed using RveMan 5.3 statistical software with fixed effects model,and expressed as standardized mean difference(SMD) with 95%confidence interval(95% CI).Results A total of 26 RCT trials were included.In the combined analysis,omega-3 PUFA supplementation had no significant effect on fasting blood glucose(FBG)(SMD=0.09,95% CI:-0.01,0.20;I^2=57%) and glycosylated hemoglobin(HbA1 c)(SMD=0.01,95% CI:0.10,-0.11;I^2=48%).In the FBG subgroup analysis,baseline blood glucose levels and omega-3 PUFA supplementation in T2 DM patients significantly affected FBG levels in T2 DM patients.Conclusion Supplementation of omega-3 PUFA may improve glucose control in patients with T2 DM,but it is recommended to supplement omega-3 PUFA at the appropriate dose based on their own blood glucose and HbAlc baseline levels.[ACTA NUTRIMENTA SINICA,2020,42(5):449-457]

关 键 词：omega-3多不饱和脂肪酸 2型糖尿病 META分析 

分 类 号：R587.1[医药卫生—内分泌]