少精子症动物模型的构建少精子症动物模型的构建  

Construction of an Animal Model of Oligospermia

作　　者：许卫 XU Wei(Department of Laboratory Medicine,the Fourth Affiliated Hospital of Zhejiang University School of Medicine,Yiwu 322000,Zhejiang,China)

机构地区：[1]浙江大学医学院附属第四医院检验科,浙江义乌322000

出　　处：《医学信息》2021年第5期46-48,共3页Journal of Medical Information

基　　金：义乌市科研计划项目(编号:20-3-261)。

摘　　要：少精子症是导致男性不育的重要原因之一,构建稳定可靠的少精子症动物模型,对研究少精子症的发生发展和治疗尤为重要。现阶段构建少精子症动物模型的方法有化疗药物,普通药物,物理方法,基因敲除等,但各种方法之间的构建效果存在一定差异。本文拟对目前少精子症动物模型构建的方法进行总结,以期为进一步筛选出效果较好的少精子症动物模型构建方法提供参考。Oligospermia is one of the important reasons leading to male infertility.The construction of a stable and reliable animal model of oligospermia is particularly important for studying the occurrence,development and treatment of oligospermia.At this stage,the methods for constructing oligospermia animal models include chemotherapy drugs,common drugs,physical methods,gene knockout,etc.However,there are certain differences in the construction effects between various methods.This article intends to summarize the current methods of constructing oligospermia animal models,hoping to provide a reference for further screening out better oligospermia animal models.

关 键 词：少精子症 动物模型构建 不育 

分 类 号：R256.23[医药卫生—中医内科学]