稽留流产患者血清和尿液中8羟基脱氧鸟苷的检测及临床意义  

Detection and clinical significance of 8 hydroxydeoxyguanosine in serum and urine of patients with missed abortion

作　　者：周燕妮 钟苏云 方川 杨红文 ZHOU Yan-ni;ZHONG Su-yun;FANG Chuan;YANG Hong-wen(Department of Gynecology,Futian District Maternal and child health hospital,Shenzhen Guangdong,518045)

机构地区：[1]广东省深圳市福田区妇幼保健院妇科,深圳518045

出　　处：《中国优生与遗传杂志》2020年第10期1235-1237,共3页Chinese Journal of Birth Health & Heredity

基　　金：2019年福田区公益性科研课题立项(FTWS2019032),项目名称:稽留流产患者血清和尿液中8羟基脱氧鸟苷的检测及临床意义。

摘　　要：目的研究稽留流产患者血清和尿液中8羟基脱氧鸟苷(8-OHdG)的检测及临床意义并进行分析,旨在为临床稽留流产的防治提供新的靶点与思路。方法将我院从2019年5月~2020年2月收治的稽留流产患者60例纳入研究,记作稽留流产组。另取同期于我院纠正的正常早孕要求流产孕妇60例作为对照组。比较两组血清和尿液中8-OHdG水平,并作Spearman相关性分析。此外,对比两组氧化应激指标水平,实施Pearson相关性分析。结果稽留流产组血清以及尿液8-OHdG水平均高于对照组(均P<0.05)。经Spearman相关性分析可得:血清、尿液8-OHdG水平与稽留流产均呈正相关关系(均P<0.05)。稽留流产组超氧化物歧化酶(SOD)、维生素E(VitE)水平均低于对照组,而丙二醛(MDA)水平高于对照组(均P<0.05)。经Pearson相关性分析可得:稽留流产患者血清、尿液8-OHdG水平与SOD、VitE水平均呈负相关关系,而与MDA水平呈正相关关系(均P<0.05)。结论 8-OHdG于稽留流产患者血清和尿液中均存在明显高表达,可作为临床稽留流产患者防治的潜在靶点。其主要作用机制可能和氧化应激状态密切相关。Objective:To study the detection and clinical significance of 8 hydroxydeoxyguanosine(8-OHdG)in serum and urine of patients with missed abortion,and to provide a new target and idea for the prevention and treatment of missed abortion.Methods:60 patients with missed abortion admitted to our hospital from May 2019 to February 2020 were included in the study and recorded as missed abortion group.In addition,60 pregnant women with normal early pregnancy who were corrected in our hospital at the same time and required abortion were taken as the control group.The serum and urine levels of 8-ohdg in the two groups were compared and Spearman correlation analysis was performed.In addition,the levels of oxidative stress indicators in the two groups were compared and Pearson correlation analysis was performed.Results:Serum and urine levels of 8-OHdG in the missed abortion group were higher than those in the control group(all P<0.05).Spearman correlation analysis showed that serum and urine 8-OHdG levels were positively correlated with missed abortion(all P<0.05).The level of superoxide dismutase(SOD)and vitamin E(VitE)in the missed abortion group was lower than that in the control group,while the level of malondialdehyde(MDA)was higher than that in the control group(all P<0.05).According to Pearson correlation analysis,serum and urine 8-OHdG levels of patients with missed abortion were negatively correlated with SOD and VitE levels,while positively correlated with MDA levels(all P<0.05).Conclusion:8-OHdG is highly expressed in serum and urine of patients with missed abortion,which can be used as a potential target for the prevention and treatment of patients with missed abortion.The main mechanism may be closely related to oxidative stress.

关 键 词：稽留流产 8-羟基脱氧鸟苷 血清 尿液 临床意义 

分 类 号：R714.21[医药卫生—妇产科学]