血浆D-二聚体联合抗凝血酶(AT)-Ⅲ检测对妊娠高血压综合征孕妇早期诊断价值分析  

Analysis of the value of plasma D-dimer combined with antithrombin(AT)-Ⅲ in early diagnosis of pregnant women with pregnancy-induced hypertension syndrome

作　　者：黄廷 涂伟[1] 李紫微 罗金林 邓文平[1] HUANG Ting;TU Wei;LI Zi-wei;LUO Jin-lin;DENG Wenping(Department of medical laboratory,Fuling Central Hospital,Chongqing,408000)

机构地区：[1]重庆市涪陵中心医院医学检验科,重庆408000

出　　处：《中国优生与遗传杂志》2020年第10期1238-1240,1251,共4页Chinese Journal of Birth Health & Heredity

基　　金：重庆市卫生计生委医学科研项目(2017ZBXM007)。

摘　　要：目的探讨血浆D-二聚体联合抗凝血酶(AT)-Ⅲ检测对妊娠高血压综合征孕妇早期诊断价值。方法选择2017年6月至2019年11月本院接诊妊娠高血压综合征孕妇110例纳入妊高症组,据病情严重程度分组:妊娠期高血压组38例,轻度子痫前期组42例,重度子痫前期组30例;同期取正常育龄期女性80例纳入对照组。探究血浆D-二聚体联合AT-Ⅲ对妊娠高血压综合征的早期诊断价值。结果妊高症组、正常妊娠组孕妇的血浆FIB、D-二聚体水平均高于常规对照组女性,且妊高症组高于正常妊娠组(P<0.05);妊高症组、正常妊娠组孕妇的APTT、PT、AT-Ⅲ值均低于常规对照组女性,妊高症组低于正常妊娠组(P<0.05);轻度子痫前期组、重度子痫前期组妊高症孕妇的血浆FIB、D-二聚体水平均高于妊娠期高血压组孕妇,重度子痫前期组高于轻度子痫前期组(P<0.05);轻度子痫前期组、重度子痫前期组妊高症孕妇的APTT、PT、AT-Ⅲ值均低于妊娠期高血压组,重度子痫前期组低于轻度子痫前期组(P<0.05);血浆联合D-二聚体联合AT-Ⅲ诊断妊娠高血压综合征的敏感度、特异度均高于血浆D-二聚体、AT-Ⅲ单独诊断(P<0.05)。结论联合检测血浆D-二聚体、抗凝血酶-Ⅲ能使临床早期诊断妊娠高血压综合征的敏感度、特异度提高,为临床判定病情严重程度提供信息。Objective:To explore the early diagnosis value of plasma D-dimer combined with antithrombin(AT)-Ⅲ detection in pregnant women with pregnancy-induced hypertension syndrome. Methods:110 cases of pregnant women with pregnancy-induced hypertension syndrome were selected from our hospital from June 2017 to November 2019. Grouped according to the severity of the disease:38 cases of hypertension during pregnancy,42 cases of mild preeclampsia,30 cases of severe preeclampsia;During the same period,80 cases of females of normal reproductive age were included in the control group. To explore the early diagnosis value of plasma D-dimer combined with AT-Ⅲ in pregnancy-induced hypertension syndrome. Results:The plasma FIB and D-dimer levels of pregnant women in pregnancy-induced hypertension group and normal pregnancy group were higher than those in routine control group,and pregnancy-induced hypertension group was higher than those in the normal pregnancy group(P<0.05);The APTT,PT,and AT-Ⅲ values of pregnant women with pregnancy-induced hypertension group and normal pregnancy group were lower than those of the conventional control group,and those of the pregnancy-induced hypertension group were lower than those in the normal pregnancy group(P<0.05);The plasma FIB and D-dimer levels in pregnant women with mild preeclampsia and severe preeclampsia are higher than those in pregnant women with hypertension,and those in severe preeclampsia are higher than those in the mild preeclampsia(P<0.05);The APTT,PT,and AT-Ⅲ values of pregnant women with mild preeclampsia and severe preeclampsia were lower than those of the hypertension group during pregnancy,while those of the severe preeclampsia group were lower than those in the mild preeclampsia group(P<0.05);The sensitivity and specificity of plasma combined with D-dimer and AT-Ⅲ in the diagnosis of pregnancy-induced hypertension syndrome were higher than those in the plasma D-dimer and AT-Ⅲ alone(P<0.05). Conclusion:The combined detection of plasma D-dimer and antithrombin-

关 键 词：D-二聚体 抗凝血酶-Ⅲ 妊娠高血压综合征 子痫前期 敏感度 特异度 

分 类 号：R714.246[医药卫生—妇产科学]