丙泊酚联合右美托咪定对老年前列腺手术患者s100β蛋白、神经元特异性烯醇化酶表达及认知的影响  

Effects of Propofol Combined with Dexmedetomidine on the Expressions of s100βProtein and Neuron Specific Enolase as well as Cognition in Elderly Patients Undergoing Prostatectomy

作　　者：王晓英[1] 张彩举[1] 付金厚[1] WANG Xiao-ying;ZHANG Cai-ju;FU Jin-hou(Department of Anesthesiology,Nanyang First People's Hospital,Nanyang 473000,China)

机构地区：[1]南阳市第一人民医院麻醉科,南阳473000

出　　处：《中国合理用药探索》2021年第2期51-55,共5页Chinese Journal of Rational Drug Use

摘　　要：目的:探究丙泊酚联合右美托咪定对老年前列腺手术患者血清s100β蛋白、神经元特异性烯醇化酶(NSE)表达及认知的影响。方法:选取2018年8月~2019年8月在本院行前列腺手术的良性前列腺增生老年患者50例作为研究对象,随机分为试验组和对照组,各25例。试验组患者于手术期间给予丙泊酚联合右美托咪定麻醉,对照组仅给予丙泊酚麻醉。观察两组患者术前1天及术后1天、3天血清s100β蛋白、NSE水平的变化,并采用简易智力状态检查量表(MMSE)对患者术前、术后各时间点的认知功能进行评价。结果:两组患者年龄、病程、体质指数及手术时间等一般资料比较均无统计学差异(P> 0.05)。术前1天,两组患者血清NSE、s100β蛋白水平比较均无统计学差异(P> 0.05);术后1天,两组患者血清NSE、s100β蛋白水平均高于术前1天(P <0.05),且试验组升高幅度低于对照组(P <0.05);术后3天,试验组血清NSE、s100β蛋白水平低于对照组(P <0.05)。术前1天,两组患者MMSE评分比较无统计学差异(P> 0.05);术后1天,两组患者MMSE评分均低于术前1天(P <0.05),且试验组降低幅度低于对照组(P <0.05);术后3天及术后3个月,试验组MMSE评分高于对照组(P <0.05)。结论:丙泊酚联合右美托咪定麻醉方式可有效降低老年前列腺手术患者脑损伤特异性血清标志物NSE、s100β蛋白水平,使患者尽快恢复正常的认知功能。Objective:To investigate the effects of propofol combined with dexmedetomidine on the expressions of serum s100βprotein,neuron specific enolase(NSE)and cognition in elderly patients undergoing prostatectomy.Methods:From August 2018 to August 2019,50 elderly patients with benign prostatic hypertrophy who underwent prostatectomy in our hospital were randomly divided into experimental group and control group,with 25 cases in each group.The patients in experimental group were anesthetized with propofol and dexmedetomidine during the operation,while the patients in control group were anesthetized with propofol alone.The changes of serum s100βprotein and NSE were observed in two groups on day before operation,the first day after operation and the third day after operation.The cognitive function of patients before and after operation was evaluated by Mini-Mental State Examination(MMSE).Results:There was no significant difference in age,course of disease,body mass index and operation time between two groups(P>0.05).And there was no significant difference in serum NSE and s100βprotein levels between two groups on the first day before operation(P>0.05).The levels of NSE and s100βprotein in two groups on the first day after operation were higher than those on the first day before operation(P<0.05),with more incensement found in experimental group than in control group(P<0.05).The levels of serum NSE and s100βprotein in experimental group were lower than those in control group on the third day after operation(P<0.05).In addition,there was no significant difference in MMSE scores between two groups on the first day before operation(P>0.05).On the first day after operation,MMSE scores of two groups were lower than that of the first day before operation(P<0.05),with more reduction found in experimental group than in control group(P<0.05).MMSE scores of experimental group were higher than that of control group on the third day and the third month after operation(P<0.05).Conclusions:Anesthesia wit propofol combined with dexm

关 键 词：丙泊酚 右美托咪定 老年前列腺 S100Β蛋白 神经元特异性烯醇化酶 认知功能 

分 类 号：R983[医药卫生—药品]