Biofabrication of aligned structures that guide cell orientation and applications in tissue engineering  

作　　者：Kejie Lu Ying Qian Jiaxing Gong Ziyu Zhu Jun Yin Liang Ma Mengfei Yu Huiming Wang 

机构地区：[1]The Affiliated Hospital of Stomatology,School of Stomatology,Zhejiang University School of Medicine,and Key Laboratory of Oral Biomedical Research of Zhejiang Province,Hangzhou 310006,China [2]The State Key Laboratory of Fluid Power and Mechatronic Systems,School of Mechanical Engineering,Zhejiang University,Hangzhou 310028,China

出　　处：《Bio-Design and Manufacturing》2021年第2期258-277,共20页生物设计与制造（英文）

基　　金：This work was financially supported by the National Key Research and Development Program of China(2018YFA0703000);the NationalNatural Science Foundation of China(81670972,31872752);Key Research and Development Program of Zhejiang,China(2017C01054,2018C03062,2017C01063);Postdoctoral Science Foundation of China(2020TQ0257,2020M681896).

摘　　要：The organized alignment of cells in various tissues plays a significant role in the maintenance of specific functions.To induce such an alignment,ideal scaffolds should simulate the characteristics and morphologies of natural tissues.Aligned structures that guide cell orientation are used to facilitate tissue regeneration and repair.We here review how various aligned structures are fabricated,including aligned electrospun nanofibers,aligned porous or channeled structures,micropatterns and combinations thereof,and their application in nerve,skeletal muscle,tendon,and tubular dentin regeneration.The future use of aligned structures in tissue engineering is also discussed.

关 键 词：Aligned structures Cell orientation Electrospun nanofibers Channeled structures MICROPATTERNS Tissue engineering 

分 类 号：R318.08[医药卫生—生物医学工程]