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作 者:卢伟达[1] 任杰[1] 张志宏[1] 朱玉辉 李炳奇 郭海玲[2] LU Wei-da;REN Jie;ZHANG Zhi-hong;ZHU Yu-hui;LI Bing-qi;GUO Hai-ling(Jilin Hospital of Integrated Traditional Chinese and Western Medicine,Jilin,lilin,China,130021;Shuguang Hospital of Shanghai University of Chinese Medicine,Shanghai,China,201203)
机构地区:[1]吉林中西医结合医院,吉林吉林130021 [2]上海中医药大学附属曙光医院,上海201203
出 处:《河南中医》2021年第3期478-482,共5页Henan Traditional Chinese Medicine
摘 要:骨碎补、牛膝、当归、丹参、杜仲是常用于治疗骨质疏松症和骨关节炎的单味中药。骨碎补中柚皮苷有促进成骨细胞合成及抑制破骨细胞生成的双重调节作用,从而缓解骨质疏松的进展;而骨碎补总黄酮可抑制骨关节炎模型的炎性介导因子,进而阻止关节软骨的破坏。当归中有效提取物可有效地缓解炎性介质对软骨和骨的破坏。牛膝提取物中雌激素类似物对骨与软骨均有保护作用,牛膝总皂苷对破骨细胞的抑制发挥了其在抗骨质疏松治疗中的作用。丹参中的丹酚酸B对成骨细胞有促进作用,同时对关节软骨也有一定的保护作用;丹参酮可抑制破骨细胞分化,也可延缓关节软骨退变。杜仲提取物可有效地调节骨代谢,提高了骨的生物力学质量。中药治疗骨质疏松症和骨关节炎的作用机理是通过全身性、多环节、多通路的调节来实现的。今后,应在中医理论的指导下,运用现代药理学在细胞分子基因水平上对中药治疗该病的作用机理进行多方位、多靶点、多环节的研究。Gusuibu(Rhizoma Drynariae),Niuxi(Radix Achyranthis Bidentatae),Danggui(Radix Angelicae Sinensis),Danshen(Radix Salviae Miltiorrhizae)and Duzhong(Cortex Eucommiae)are commonly used in the treatment of osteoporosis and osteoarthritis.Naringin in Gusuibu can promote the synthesis of osteoblasts and inhibit the formation of osteoclasts,so as to alleviate the progress of osteoporosis.The total flavonoids of Gusuibu can inhibit the inflammatory mediators of osteoarthritis model,and then prevent the destruction of articular cartilage.The effective extract of Danggui can effectively alleviate the destruction of cartilage and bone by inflammatory mediators.The estrogen analogues in Niuxi extract have protective effects on bone and cartilage,and the total saponins of Niuxi play an important role in the treatment of osteoporosis.Salvianolic acid B in Danshen can promote osteoblasts and protect articular cartilage;tanshinone can inhibit osteoclast differentiation and delay articular cartilage degeneration.Duzhong extract can effectively regulate bone metabolism and improve the biomechanical quality of bone.The mechanism of action of Chinese medicinals in the treatment of osteoporosis and osteoarthritis is realized through systemic,multi-link and multi-channel regulation.In the future,multi-directional,multi-target,multi link research on the mechanism of the disease at the level of cell,molecule and gene should be carried out under the guidance of the theory of TCM.
关 键 词:骨质疏松症 骨关节炎 骨碎补 当归 牛膝 丹参 杜仲
分 类 号:R274.983[医药卫生—中西医结合]
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