珠海地区353例儿童喘息性疾病病毒病原学分析  

Analysis of the virus etiology of 353 children with wheezing disease in Zhuhai area

作　　者：黄翩翩[1] 邹商群[1] 肖鸽飞[1] 贾晓芸[1] 陶维井 戴其强 HUANG Pianpian;ZOU Shangqun;XIAO Gefei;JIA Xiaoyun;TAO Weijing;DAI Qiqiang(Department of Pediatrics,Zhuhai Maternal and Child Health Care Hospital,Zhuhai,Guangdong,China,519000;Guangzhou DaAn Clinical Laboratory Center,Guangzhou,Guangdong,China,510665)

机构地区：[1]珠海市妇幼保健院,广东珠海519000 [2]广州达安临床检验中心,广东广州510665

出　　处：《分子诊断与治疗杂志》2021年第2期195-198,共4页Journal of Molecular Diagnostics and Therapy

基　　金：广东省医学科学技术研究基金项目(A2017443)。

摘　　要：目的探讨儿童喘息性疾病的病毒病原学特征,提高临床诊治水平。方法收集本院儿科2018年6月至2019年5月353例喘息患儿的咽拭子,应用多重PCR技术对病毒进行检测,并分析临床资料。结果病毒检测阳性124例(35.13%),呼吸道合胞病毒(RSV)77例(21.81%)、副流感病毒(PIV)14例(3.97%)、博卡病毒(HBoV)11例(3.11%)、人偏肺病毒(HMPV)10例(2.83%)、鼻病毒(HRV)9例(2.55%)、腺病毒(ADV)4例(1.13%)、流感病毒A型(INF-A)1例(0.28%),流感病毒B型(INF-B)0例(0%)。混合病毒感染3例(0.85%),28天~3岁喘息患儿共340例,占96.32%。结论喘息病例检出率高的病毒病原体为呼吸道合胞病毒,混合病毒感染少见,28天~3岁幼儿为喘息性疾病高发年龄。Objective To explore the viral etiological characteristics of children's wheezing dis⁃eases and improve the level of clinical diagnosis and treatment.Methods The throat swabs of 353 wheezing children from June 2018 to May 2019 were collected from the Pediatric Department of this Hospital,and multi⁃ple PCR technology was used to detect the virus and analyze clinical data.Results Eight viruses nucleic ac⁃ids were detected by throat swabs in 353 cases.124 cases(35.13%)were positive for the virus,77 cases(21.81%)for respiratory syncytial virus(RSV),14 cases(3.97%)for parainfluenza virus(PIV),11 cases(3.11%)for Boca virus(HBoV),Human metapneumovirus(HMPV)10 cases(2.83%),rhinovirus(HRV)9 cases(2.55%),adenovirus(ADV)4 cases(1.13%),influenza virus type A(INF⁃A)1 case(0.28%),0 cases(0%)of influenza virus type B(INF⁃B).There were 3 cases of mixed virus infection(0.85%),340 cas⁃es of wheezing children from 28 days to 3 years old,accounting for 96.32%.Conclusion The viral pathogen with a high detection rate of wheezing cases is respiratory syncytial virus,and mixed viral infections are rare.Children between 28 days and 3 years old are the age at which wheezing diseases occur.

关 键 词：儿童 喘息 病毒 病原学 

分 类 号：R725.6[医药卫生—儿科]