鲜益母草胶囊促进药物流产不全大鼠子宫复旧的实验研究  

Experimental Study on Promotion Effect of Fresh Leonurus Japonicus Capsule(鲜益母草胶囊)on Uterine Involution of Incomplete Drug Abortion Rat

作　　者：栾会玲 业康 金祖汉[1] 金捷[1] 黄晶晶[1] 杨明华[1] LUAN Huiling;YE Kang;JIN Zuhan;JIN Jie;HUANG Jingjing;YANG Minghua(Zhejiang Research Institute of Chinese Medicine Co.,Ltd,Hangzhou,Zhejiang 310023)

机构地区：[1]浙江省中药研究所有限公司,浙江杭州310023

出　　处：《中国中医药科技》2021年第2期200-203,共4页Chinese Journal of Traditional Medical Science and Technology

摘　　要：目的:观察鲜益母草胶囊对药物流产不全大鼠的子宫复旧的影响。方法:采用米非司酮(8.3 mg/kg)和米索前列醇(100μg/kg)建立大鼠药物不完全流产模型,实验分为正常组、模型组、益母草胶囊(0.946 g/kg)阳性对照组和鲜益母草胶囊低、中、高剂量(0.18、0.36、0.72 g/kg)组,成模后连续给药7 d.观察鲜益母草胶囊对药物流产不全大鼠子宫出血时间、出血量、卵巢和子宫指数、子宫形态及子宫病理变化的影响。结果:鲜益母草胶囊能减少药物流产不全大鼠子宫出血量(P<0.05),缩短出血时间(P<0.01),降低子宫指数,明显减少宫内滞留物,促进子宫复旧。结论:鲜益母草胶囊能明显抑制药物不完全流产大鼠的子宫出血,促进子宫复旧。Objective:To investigate the effects of Fresh Leonurus Japonicus Capsule on uterine involution of incomplete drug abortion on rat.Methods:To establish the incomplete drug abortion rat model with 8.3 mg/kg mifepristone and 100μg/kg misoprostol,experiment was divided into normal,model,Leonurus Japonicus Capsule(0.946 g/kg)positive group and Fresh Leonurus Japonicus Capsule low,middle and high dose(0.18、0.36、0.72 g/kg)groups,each group was given NS or medicine for 7 days after modeling.Observing the effects of Fresh Leonurus Japonicus Capsule on the amount of uterine bleeding,bleeding time,uterine morphology,uterine pathology,ovarian and uterine index.Results:Fresh Leonurus Japonicus Capsule reduced uterine bleeding amount(P<0.05),shortened bleeding time(P<0.01),lowered uterine index,significantly reduced fetal residual and promoted the uterine involution.Conclusion:Fresh Leonurus Japonicus Capsule can significantly inhibit uterine bleeding and promote the uterine involution in rats after incomplete drug abortion.

关 键 词：鲜益母草胶囊 药物流产不全 子宫 病理学 大鼠 

分 类 号：R285.5[医药卫生—中药学]