白杨素Mannich衍生物的合成及其抗IgE介导Ⅰ型过敏反应活性研究  

Synthesis and Anti-typeⅠAllergy Effect of Chrysin Mannich base Derivatives

作　　者：徐军[1] 杨美林[1] 仲崇琳 XU Jun;YANG Meiling;ZHONG Chonglin(Jilin Academy of Chinese Medicine Sciences,Changchun,Jilin 130012)

机构地区：[1]吉林省中医药科学院,吉林长春130012

出　　处：《中国中医药科技》2021年第2期203-207,共5页Chinese Journal of Traditional Medical Science and Technology

基　　金：吉林省中医药科技项目(2020109)。

摘　　要：目的:本文设计合成一系列白杨素Mannich衍生物,并进行其抗IgE介导的Ⅰ型过敏反应活性研究。方法:Ⅰ型过敏反应大鼠模型采用卵白蛋白(OVA)和氢氧化铝[Al(OH)3]的混合溶液致敏法诱导而成,并进行动物体内抗炎活性研究。结果:低、高剂量(40 mg·kg^(-1)、80 mg·kg^(-1))的4个新化合物的抗过敏反应活性均高于白杨素;其中,化合物1a-1d可显著降低血清中的免疫球带白E(IgE)和白三烯(LT)含量,化合物1a、1b、1d可减少全血和肺泡灌洗液(BALF)中的嗜酸性粒细胞(EOS)数量及肺组织炎症面积,综合各项检测指标,抗炎活性强弱次序为:1b>1c>1d>1a>白杨素。结论:合成的新白杨素Mannich衍生物结构新颖,抗炎效果较好。Objective:A series of Chrysin mannich base derivatives(1a-1d)were synthesized and anti-typeⅠallergy effect of Chrysin mannich base derivatives was detected.Methods:Rats were sensitized with the mixture of OVA and Al(OH)3 to establish the experimental animal model of typeⅠallergy and the anti-inflammatory activities in vivo were evaluated.Results:All the new compounds showed better anti-inflammatory activities than starting compounds at dose of 40 mg·kg^(-1)and 80 mg·kg^(-1).1a-1d could decrease the contents of IgE and LT in serum;1a,1b,1d could reduce the quantities of EOS in whole blood and BALF;1a-1d could reduce the inflammatory area in pulmonary tissue.Compounds 1a-1d could inhibit IgE mediated typeⅠallergy,the activity sequence was 1b>1c>1d>1a>Chrysin.Conclusion:These new Chrysin mannich base derivatives have novel structure and good anti-inflammatory effect.

关 键 词：白杨素曼尼希碱衍生物 过敏反应 免疫球蛋白E 白三烯 嗜酸性粒细胞 

分 类 号：R285.5[医药卫生—中药学]