尼可地尔对急性心肌梗死患者心功能及心肌微循环的影响  

Effects of Nicorandil on Cardiac Function and Myocardial Microcirculation in Patients with Acute Myocardial Infarction

作　　者：牛靖[1] NIU Jing(Nanyang First People's Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市第一人民医院,河南南阳473000

出　　处：《药品评价》2021年第1期41-43,共3页Drug Evaluation

摘　　要：目的:探究尼可地尔对急性心肌梗死患者心功能及心肌微循环的影响。方法:选取2018年9月至2019年9月南阳市第一人民医院收治的行经皮冠状动脉介入治疗(PCI)的急性心肌梗死患者80例。按照随机数字表法,分为对照组和观察组,各40例。对照组于PCI术前后给予阿司匹林和氯吡格雷,观察组在对照组基础上在冠脉内注射尼可地尔。比较两组患者心功能[左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)及左室射血分数(LVEF)]和心肌微循环,并记录术后心血管不良事件发生情况。结果:术后,两组患者LVESD、LVEDD水平低于术前,LVEF水平高于术前;且观察组患者LVESD、LVEDD水平低于对照组,LVEF水平高于对照组,差异均有统计学意义(P<0.05);两组患者心肌微循环各指标明显低于术前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组心血管不良事件发生率明显低于对照组(12.50%vs32.50,P<0.05)。结论:尼可地尔可有效改善急性心肌梗死患者的心功能和心肌微循环,降低术后心血管不良事件发生率。Objective:To explore the effect of nicorandil on cardiac function and myocardial microcirculation in patients with acute myocardial infarction.Methods:80 patients with acute myocardial infarction who underwent percutaneous coronary intervention(PCI)in Nanyang First People's Hospital from September 2018 to September 2019 were selected.According to the random number table method,they were divided into control group and observation group,40 cases in each group.The control group was given aspirin and clopidogrel before and after PCI,and the observation group was injected with nicorandil in the coronary artery on the basis of the control group.The cardiac function[left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF)]and myocardial microcirculation were compared between the two groups,and the incidence of postoperative cardiovascular adverse events was recorded.Results:After operation,the level of LVESD and LVEDD in the two groups was significantly lower than that before operation(P<0.05).LVEF level was significantly higher than that before operation in the same group(P<0.05).After operation,LVESD and LVEDD levels in the observation group were significantly lower than those in the control group(P<0.05),and LVEF levels were significantly higher than those in the control group(P<0.05).The indexes of myocardial microcirculation in the two groups were significantly lower than before operation,and the observation group was lower than the control group,the difference was statistically significant.The incidence of cardiovascular adverse events in the observation group was significantly lower than that in the control group(12.50%vs 32.50,P<0.05).Conclusion:Nicorandil can effectively improve cardiac function and myocardial microcirculation in patients with acute myocardial infarction,and reduce the incidence of postoperative cardiovascular adverse events.

关 键 词：心肌梗死 尼可地尔 经皮冠状动脉介入治疗 心功能 心肌微循环 

分 类 号：R542.22[医药卫生—心血管疾病]