远隔缺血适应心肌保护作用的体液传递途径  

The humoral mechanism of remote ischemia conditioning on myocardial protection

作　　者：艾丽玛·艾尔肯 何立芸[1] 王贵松[1] Ailima·Ai'erken;He Liyun;Wang Guisong(Department of Cardiology,Peking University Third Hospital,NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing Key Laboratory of Cardiovascular Receptors Research,Beijing 100191,China)

机构地区：[1]北京大学第三医院心内科,血管医学研究所,国家卫生健康委员会心血管分子生物学与调节肽重点实验室,分子心血管学教育部重点实验室,心血管受体研究北京市重点实验室,北京100191

出　　处：《中国医学前沿杂志（电子版）》2021年第3期77-81,共5页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：国家自然科学基金面上项目(81870271)。

摘　　要：早期再灌注治疗是急性ST段抬高心肌梗死(ST segment elevation myocardial infarction,STEMI)的有效治疗方法,然而,缺血再灌注损伤(ischemia-reperfusion injury,IRI)严重影响患者的近期和远期预后。远隔缺血适应(remote ischemic conditioning,RIC)是减少IRI的新兴疗法,近年来针对RIC的心肌保护机制进行了大量的研究及讨论,发现体液途径在其中发挥着重要作用。本文将聚焦于体液途径在RIC中的心肌保护作用,总结相关的研究进展,概述RIC可能的循环介质。Early reperfusion therapy is an effective treatment of acute ST segment elevation myocardial infarction(STEMI).However,ischemia-reperfusion injury(IRI)severely affects the short-term and long-term prognosis of patients.Remote ischemic conditioning(RIC)is an emerging therapy to reduce IRI.In recent years,a large number of studies and discussions have been involved in the protective mechanism of RIC,and it was found that the humoral pathway plays an important role in it.This article will focus on the role of humoral mechanisms in the myocardial protection of RIC,the relevant research progress and the possible circulating mediators will be reviewed.

关 键 词：缺血再灌注损伤 远隔缺血适应 心肌保护 体液因子 

分 类 号：R542.22[医药卫生—心血管疾病]