加减逍遥散联合雌孕激素序贯治疗对继发性闭经患者临床疗效及血清FSH、LH、PRL、AMH水平的影响  

Effects of Addition and Subtraction of Xiaoyao Powder Combined with Sequential Treatment of Estrogen Progesterone on Clinical Efficacy and Serum Levels of FSH,LH,PRL and AMH in Patients with Secondary Amenorrhea

作　　者：刘莉莉 王娟娟 王敏妨 黄向东 LIU Lili;WANG Juanjuan;WANG Minfang;HUANG Xiangdong(Department of TCM Gynecology, Zhangjiakou Hospital of Traditional Chinese Medicine, Zhangjiakou 075000,China;Department of Obstetrics and Gynecology, Army Hospital of the 81st Group, Zhangjiakou 075000,China;Department of Traditional Chinese Medicine, Zhangjiakou Hospital of traditional Chinese Medicine, Zhangjiakou 075000,China)

机构地区：[1]张家口市中医院中医妇科,河北张家口075000 [2]陆军第八十一集团军医院妇产科,河北张家口075000 [3]张家口市中医院中医科,河北张家口075000

出　　处：《标记免疫分析与临床》2021年第2期273-277,325,共6页Labeled Immunoassays and Clinical Medicine

基　　金：张家口市科技计划项目(编号:1921108D)。

摘　　要：目的探究加减逍遥散联合雌孕激素序贯治疗对继发性闭经患者临床疗效及血清卵泡刺激素(FSH)、促黄体生成素(LH)、催乳素(PRL)、抗缪勒管激素(AMH)水平的影响。方法选取本院妇科门诊2019年1月至2019年8月符合标准的60例继发性闭经患者,按照随机数字表法将其分为治疗组和对照组,各30例。对照组给予雌孕激素序贯治疗,治疗组在前者基础上加用加减逍遥散治疗。观察2组患者治疗后总有效率、治疗前后中医症候积分、月经恢复情况(包括基础体温变化、月经恢复时间、月经周期恢复时间)、治疗前后患者内分泌情况(血清FSH、LH、PRL、AMH及FSH/LH水平)以及不良反应发生率。结果经治疗后,治疗组总有效率93.33%明显高于对照组70.00%(P<0.005)。2组患者治疗前血清PRL(治疗组35.67±5.42ng/mL、对照组35.89±5.74ng/mL)、AMH(治疗组1.82±0.54ng/mL、对照组1.78±0.52ng/mL)、FSH(治疗组36.52±15.47IU/L、对照组36.87±15.64IU/L)、LH水平(治疗组9.86±3.12IU/L、对照组10.01±3.22IU/L)、FSH/LH(治疗组3.82±0.45、对照组3.76±0.37)及中医症候积分(治疗组4.82±1.23分、对照组4.67±1.18分)比较,差异无统计学意义(P均>0.05)。治疗后,2组中医症候积分(治疗组2.13±0.12分、对照组3.64±0.76分)、血清PRL(治疗组15.26±3.21ng/mL、对照组24.63±4.57ng/mL)、FSH(治疗组12.23±2.78IU/L、对照组15.69±3.12IU/L)水平及FSH/LH(治疗组1.26±0.21、对照组1.87±0.24)较治疗前明显降低(P<0.05),且治疗组明显低于对照组(P<0.05);血清AMH水平(治疗组4.56±1.03ng/mL、对照组3.47±0.82ng/mL)较治疗前明显升高(P<0.05),且治疗组明显高于对照组(P<0.05);血清LH水平(治疗组7.94±2.23IU/L、对照组7.32±1.98IU/L)较治疗前明显降低(P<0.05),2组间比较差异无统计学意义(P>0.05)。治疗组治疗前后基础体温差值(0.28±0.11℃)明显高于对照组(0.07±0.03℃,P<0.05),月经质、量恢复时间(62.5±6.2d)及月经周期恢�Objective To investigate the effects of additive and subtractive Xiaoyaoshan combined with sequential treatment of estrogen progesterone on the clinical efficacy and serum levels of FSH,LH,PRL and AMH in patients with the secondary amenorrhea.Methods A total of 60 patients with the secondary amenorrhea who met the standard from January,2019 to August,2019 were selected and divided into the treatment group and control group,with 30 cases in each group.The control group was given sequential treatment of estrogen and progesterone,and the treatment group was treated with Jiajian Xiaoyao powder in addition of the former treatment.The total effective rate,TCM symptom score before and after treatment,menstrual recovery(including basal body temperature change,menstrual recovery time,menstrual cycle recovery time),endocrine status(serum FSH,LH,PRL,AMH and FSH/LH levels)before and after treatment and adverse reactions were all observed.Results After treatment,the total effective rate of the treatment group was 93.33%,which was significantly higher than that of the control group(70.00%)(P<0.005).There was no significant difference in the levels of PRL(treatment group 35.67±5.42ng/mL,control group 35.89±5.74ng/mL),AMH(treatment group 1.82±0.54ng/mL,control group 1.78±0.52ng/mL),FSH(treatment group 36.52±15.47IU/L,control group 36.87±15.64IU/L)and LH(treatment group 9.86±3.12IU/L,control group 10.01±3.22IU/L),FSH/LH(treatment group 3.82±0.45,control group 3.76±0.37)and TCM syndrome scores treatment group 4.82±1.23,control group 4.67±1.18 between the two groups before treatment(P>0.05).After treatment,the TCM symptom score treatment group 2.13±0.12,control group 3.64±0.76),serum PRL treatment group 15.26±3.21ng/mL,control group 24.63±4.57ng/mL),FSH(treatment group 12.23±2.78IU/L,control group 15.69±3.12IU/L)levels and FSH/LH(treatment group 1.26±0.21,control group 1.87±0.24)of the two groups were significantly lower than those of before treatment(P<0.05),and the treatment group was significantly lower than

关 键 词：加减逍遥散 雌孕激素 继发性闭经 中医症候积分 内分泌情况 

分 类 号：R271.112[医药卫生—中医妇科学]