高血压合并急性缺血性脑卒中患者血清Gal-3水平与预后的关系  

The Relationship Between the Level of Serum Gal-3 and the Prognosis of Patients with Hypertension and Acute Ischemic Stroke

作　　者：黄名新 邓晓清 HUANG Mingxin;DENG Xiaoqing(Department of Internal Medicine, Guangxi Medical University Kaiyuan Langdong Hospital, Nanning 530028, China)

机构地区：[1]广西医大开元埌东医院内二科,广西南宁530028

出　　处：《标记免疫分析与临床》2021年第2期309-312,317,共5页Labeled Immunoassays and Clinical Medicine

基　　金：南宁市科学研究与技术开发项目(编号:20163117)。

摘　　要：目的探究血清半乳糖凝集素-3(galectin-3,Gal-3)水平与高血压合并急性缺血性脑卒中患者预后的关系。方法选取2019年3月至2020年2月我院就诊的120例高血压合并急性缺血性脑卒中患者,设为观察组,同时选取同期60例高血压无合并缺血性脑卒中患者作为高血压组,选取60名体健志愿者作为对照组。观察组患者入组后根据美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS),将其分为轻症组,中症组,重症组。治疗90 d后进行相关随访,根据mRS评分(改良Rankin量表,modified rankin scale,mRS)将患者分为预后良好组与预后不良组。采用酶联免疫吸附试验(ELISA)检测各组患者血清Gal-3表达水平,分析血清Gal-3表达水平与患者病情严重程度及预后的关系,绘制受试者工作特征曲线(ROC)分析血清Gal-3表达水平对高血压合并急性缺血性脑卒中患者的预后价值。结果治疗前观察组患者血清Gal-3表达水平显著高于高血压组及对照组患者,差异具有统计学意义(P<0.05),且观察组患者血清GAL-3水平随病症严重程度而显著上升,组间差异具有统计学意义;预后良好组患者血清Gal-3水平显著低于预后不良组患者,差异具有统计学意义(P<0.05);血清Gal-3相关性分析结果如下,血清Gal-3表达水平与NIHSS评分及mRS评分呈正相关(r分别为0.675、0.525,P<0.05),血清Gal-3表达水平ROC曲线下面积(AUC)分别为0.789,其诊断灵敏度、特异性分别为74.95%、72.77%。结论血清Gal-3水平与高血压合并急性缺血性脑卒中患者疾病严重程度与预后结果呈正相关,可作为该病严重程度诊断及预后评价指标。Objective To explore the prognosis value of serum galectin-3(Gal-3)in hypertension patients with acute ischemic stroke.Methods 120 patients with hypertension complicated with acute ischemic stroke in our hospital from March,2019 to February,2020 were selected as the observation group,while 60 cases of hypertension subjects without ischemic stroke in the same period were selected as the hypertension group,and 60 healthy volunteers were selected as the control group.Patients in the observation group were further divided according to NIHSS score and mRS score.Enzyme linked immunosorbent assay(ELISA)was conducted to detect the expression level of serum Gal-3.The relationship between serum Gal-3 expression level and severity was evaluated by Spearman analysis.Receiver operating characteristic curve(ROC)was drawn to analyze the prognostic value of serum Gal-3 expression level in patients with hypertension and acute ischemic stroke.Results Serum Gal-3 in the observation group was significantly higher than that in the hypertension group and the control group at baseline(P<0.05),and the serum Gal-3 level of the observation group increased significantly with the severity of the disease.Additionally,serum Gal-3 in the good prognosis group was significantly lower than that in the bad prognosis group(P<0.05).Expression level of serum Gal-3 was positively correlated with NIHSS score and mRS score(r=0.675,0.525,P<0.05),and the area under ROC curve(AUC)of Gal-3 expression level was 0.789,with diagnostic sensitivity and specificity of 74.95%and 72.77%,respectively.Conclusion Serum Gal-3 is positively correlated with the severity of the disease and the prognosis in patients with hypertension and acute ischemic stroke,suggesting a good prognosis value.

关 键 词：血清半乳糖凝集素-3 高血压 急性缺血性脑卒中 

分 类 号：R544.1[医药卫生—心血管疾病]