定量CT研究椎后肌群体质成分与年龄的关系及变化趋势  

Relationship between posterior vertebral muscles composition and age by quantitative computed tomography

作　　者：李新彤[1] 钱占华[1] 冯强强[1] 王玲[1] 娄路馨[1] 程晓光[1] 于爱红[1] 赵凯平[2] Li Xintong;Qian Zhanhua;Feng Qiangqiang;Wang Ling;Lou Luxin;Cheng Xiaoguang;Yu Aihong;Zhao Kaiping(Department of Radiology,Beijing Jishuitan Hospital,Beijing 100035,China;Department of Medical Record Management and Statistics,Beijing Jishuitan Hospital,Beijing 100035,China)

机构地区：[1]北京积水潭医院放射科,北京100035 [2]北京积水潭医院病案统计科,北京100035

出　　处：《中华健康管理学杂志》2021年第1期44-48,共5页Chinese Journal of Health Management

基　　金：国家自然科学基金面上项目(81971617);北京市医院管理局临床医学发展专项经费资助(XMLX201843)。

摘　　要：目的探讨成人腰部椎后肌群体质成分与年龄的关系及变化趋势。方法对865例21~83岁的志愿者行腰椎CT检查,其中男性347例,年龄(44.0±12.6)岁,女性518例,年龄(45.3±13.6)岁,并以10岁的间隔划分年龄组。使用定量CT测量L3椎体中部层面椎后肌群的肌肉面积、脂肪面积及肌肉脂肪浸润程度(MFI)。使用方差分析进行组间线性趋势估计,使用独立样本t检验比较同性别相邻年龄组间及同年龄组不同性别间椎后肌群体质成分的差异,使用相关分析研究椎后肌群体质成分与年龄、体质指数、身高及体重的关系,并使用单变量线性回归分析比较年龄对椎后肌群体质成分影响的性别差异。结果男女椎后肌群的脂肪面积及MFI随年龄有增加趋势,肌肉面积随年龄有下降趋势(男性F=54.603、71.524、37.458,女性F=317.808、436.105、45.210,均P<0.001)。年龄与男女椎后肌群脂肪面积呈正相关(r=0.505、0.588,P<0.001),与MFI呈正相关(r=0.489、0.646,P<0.001),与肌肉面积呈负相关(r=-0.334、-0.367,P<0.001)。年龄对椎后肌群脂肪面积、肌肉面积及MFI的影响存在性别差异(t=-4.799、28.810、-11.027,均P<0.001)。BMI与椎后肌群脂肪面积、肌肉面积、MFI均呈正相关(r=0.414、0.420、0.184,均P<0.001)。结论成人椎后肌群在20~39岁达到发育高峰,之后随年龄的增长而出现肌肉萎缩及脂肪浸润;女性椎后肌群的退变速率较男性快,有更强的年龄依赖;年龄、BMI是影响椎后肌群体质成分的重要因素。Objective To investigate the age-related changes in the composition of lumbar posterior vertebral muscles in adults.Methods A total of 865 adults(aged 21-83 years)who underwent computed tomography scans of the lumbar spine were divided into groups by age intervals of 10 years.The fat area,muscle area,and muscle fat infiltration(MFI)of the posterior vertebral muscles at the L3 level were measured by quantitative computed tomography(QCT).Analysis of variance was used to estimate the linear trend between groups.An independent samples t-test was used to compare the composition of lumbar posterior vertebral muscles between groups.Correlation analysis was used to determine the relationships between the muscles composition with age,BMI,height,and weight.Univariate linear regression analysis was used to compare gender differences in the effect of age on the composition of posterior vertebral muscles.Results The fat area and MFI of posterior vertebral muscles of males and females increased with age,while the muscle area decreased with age(F=54.603,71.524,37.458 for males and F=317.808,436.105,45.210 for females,all P<0.001).Age was positively correlated with posterior vertebral muscles′fat area in males and females(r=0.505,0.588,both P<0.001).Age was positively correlated with MFI(r=0.489,0.646,both P<0.001)and negatively correlated with muscle area(r=-0.334,-0.367,both P<0.001).The influence of age on the fat area,muscle area,and MFI of posterior vertebral muscles differed by gender(t=-4.799,28.810,-11.027,all P<0.001).The fat area,muscle area,and MFI of posterior vertebral muscles were positively correlated with BMI(r=0.414,0.420,0.184,all P<0.001).Conclusion Posterior vertebral muscles of adults reach the peak of development at the age of 20-39 years;subsequently,the muscle atrophy and fat infiltration occur with the increase in age.The degeneration rate of female posterior vertebral muscles is faster than that of males and have stronger age dependence.Age and BMI are major factors affecting the composition of poster

关 键 词：腰椎 肌肉衰减征 年龄因素 

分 类 号：R816.8[医药卫生—放射医学]