新型冠状病毒肺炎死亡病例的临床特点分析  

Clinical characteristics of 21 cases of COVID-19 induced death: A retrospective study

作　　者：江万里[1] 魏洪垚 刘靖[2] JIANG Wanli;WEI Hongyao;LIU Jing(Department of Thoracic Surgery;Outpatient Department,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院胸外科,湖北武汉430060 [2]武汉大学人民医院门诊部,湖北武汉430060

出　　处：《西安交通大学学报（医学版）》2021年第2期197-200,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：中央高校基本科研业务费资助(No.2042019kf0057);湖北省自然科学基金(青年)资助(No.2019CFB307)。

摘　　要：目的探讨新型冠状病毒肺炎(COVID-19)死亡病例的临床特征并分析死亡原因。方法回顾性分析2020年1月27日至2020年2月25日,收住武汉大学人民医院的21例COVID-19死亡患者的临床资料,比较患者死亡前与发病早期实验室检查结果变化,并分析患者死亡原因。结果 21例死亡患者中,单纯性呼吸衰竭死亡13例(61.9%),呼吸衰竭合并心肌损伤4例(19%),呼吸衰竭合并肾衰竭2例(9.5%),呼吸衰竭合并休克2例(9.5%)。与发病早期相比,患者在临终前有白细胞计数及D-二聚体、氨基末端脑钠肽前体、超敏C反应蛋白显著增加(P<0.05),淋巴细胞计数显著降低(P<0.05)。结论有效监测心功能、肾功能、感染程度,准确评估疾病进展,及时干预,对降低COVID-19患者死亡率有积极作用。Objective To investigate the clinical characteristics of COVID-19 induced deaths and analyze the causes of death. Methods This was a hospital-based, retrospective, observational cohort study involving hospitalized patients diagnosed with COVID-19 in People’s Hospital of Wuhan University during January 27 and February 25, 2020. The clinical data of identified patients who had died of COVID-19 were retrieved and reviewed. We analyzed the death causes and compared the changes in laboratory findings between patients before death and early onset to summarize the inherent clinical characteristics. Results We recorded a total of 21 deaths, 61.9% of which had occurred due to simple respiratory failure, followed by respiratory failure with myocardial injury(19%), respiratory failure with renal failure(9.5%), and respiratory failure with shock(9.5%). At the late time, lab test data indicated that white blood cells, D-dimer, amino-terminal brain natriuretic peptide precursors, and hypersensitive C-reactive protein significantly increased while counts of lymphosyte significantly decreased(P<0.05). Conclusion Continuous monitoring of cardiac function, renal function, and infection severity can assess the disease progression accurately. Moreover, timely intervention has a positive effect in reducing COVID-19 mortality.

关 键 词：新型冠状病毒肺炎 死亡病例 临床特征 

分 类 号：R195.4[医药卫生—卫生统计学]